Sentences with phrase «tumor lesions of»

Tumor heterogeneity, i.e., the differences between cells within one tumor, among different tumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future therapy.

Not exact matches

«Animal studies and in - vitro studies with human cells have repeatedly shown that food - grade carrageenan causes gastrointestinal inflammation and higher rates of intestinal lesions, ulcerations, and even malignant tumors.»

This pilot research builds on an earlier study by Milovancev and collaborators that examined the ability of MRIs and CT angiograms to detect cancerous lesions related to FISS, and another study that looked at three methods for assessing margins for canine mast cell tumors and soft tissue sarcomas.

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

The tracer was able to successfully identify 3 out of 4 primary tumors, all 14 metastatic lymph nodes and, significantly, was able to identity all 20 of the bone lesions in the patients.

This stress, which is notably induced in pre-cancerous lesions, is characterised by an increased DNA replication rate, which provokes DNA damage and genome instability, major drivers of tumor formation.

«For men initially diagnosed with low - risk prostate cancer, MRI - ultrasound confirmatory biopsy including targeting of suspicious lesions seen on MRI results in frequent detection of tumors,» the study states.

To understand how these multi-colored lesions originated they examined blood from these mice and found that tumor cells in circulation frequently occurred as clusters comprised of different colored cancer cells.

These lesions normally remain dormant, but a steady dose of cancer promoters in the diet may override natural defenses against the growth of tumors.

Set up as a mock - trial, the session was designed to examine the increasingly common dilemma of whether evidence such as MRI images, which can be used to see damage in the brain such as lesions or tumors, should be entered into court cases.

The researchers found that OTL38 accumulated in FRα - positive tumors and metastases, and enabled the surgeons to remove an additional 29 percent of malignant lesions (confirmed by pathological examination of the resected tumors) that could not be identified with naked eyes and / or palpation.

Taking nutritional supplements containing antioxidants may unintentionally hasten the progression of a small tumor or premalignant lesion, neither of which is possible to detect.

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL)-- a rare type of non-Hodgkin lymphoma that affects the skin.

Basing treatment decisions on the metastatic lesions and the cfDNA, rather than the primary tumor, led to medication changes in 32 percent of cases (9 out of 28).

Primary tumor size was measured by weight, and the number of metastases was determined by counting lung metastatic lesions.

We also examined the expression of miR - 7 and KLF4 in brain - metastatic lesions and found that these genes were significantly down - or upregulated, respectively, in the tumor cells in brain.

To further validate the clinical significance of miR - 7 and KLF4 in brain metastasis of breast cancer, we microdissected tumor tissues from both primary and brain metastatic lesions followed by conducting TaqMan qRT - PCR.

This could explain why, in about half of the breast tumors, including premalignant lesions, that the team studied at both UC San Francisco and at Sanford Burnham Medical Research Institute, when TGF - β1 signaling was highly activated, the levels of p53 were reduced, and vice versa - if the TGF - β1 pathway was reduced, there were high levels of p53.

All of these imaging studies have limitations — CT or EUS may not identify very small tumors or metastatic lesions.

EUS is a minimally invasive procedure used to diagnose and manage a wide range of gastrointestinal cancers and pre-cancerous lesions, including pancreatic tumors.

In the classical model of tumor dissemination, specialized cells at the invasive front undergo epithelial - mesenchymal transition (EMT) and enter peripheral tumor - coalescing blood vessels to establish metastatic lesions by extravasation of CTCs.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLC).

«The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell Metabolism, Feb. 8, 2012.

Inclusion Criteria: • Availability of tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion critumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion criTumor type specific exclusion criteria

This hematoxylin and eosin stained slide of a surgically removed (resected) primary pancreatic tumor shows a cluster of immune cells (lymphoid aggregate) observed next to a pancreatic tumor lesion in a patient treated with a GM - CSF vaccine 2 weeks before surgical removal of the primary tumor.

(E and F) Representative H&E staining (E) and quantification (F) of stained tumor area of bone lesions.

(G and H) Representative H&E staining (G) and quantification of H&E - stained tumor area of bone lesions.

Despite a large amount of work that has concentrated on understanding colon tumor formation, we still do not know the full complement of molecular lesions that are individually necessary (and together sufficient) to cause colorectal cancer.

Of those, 6 percent saw their tumor lesions disappear.

Complete response, commonly referred to as CR, is the complete disappearance of a tumor or cancer lesion as a result of treatment.

Partial response, commonly referred to as PR, is a partial decrease in the size of a cancerous tumor or a decrease in the total number of cancer lesions.

Harold Varmus: Well the simplistic way to think about that is and I'm not sure this is the way it will be worked out, is to be able to take just a few cells from those early lesions and examine them genetically or for other kinds of marks on the DNA that would predict whether or not this is some - this is a lesion which might or an early stage growth that might never be able to progress, but it is also possible that every early tumor of that kind has some probability of expanding and invading and growing to become a medical problem, so getting that right will obviously be crucial because it's very difficult to say when you've diagnosed something that is an early stage tumor that it won't progress.

To further examine systemic antitumor responses, a CALM study extension [21] evaluated sequential tumor biopsies of both injected and noninjected lesions in a cohort of 13 patients.

Those who do not respond to pembrolizumab immunotherapy lack a certain type of immune cell inside their tumor lesions.

My main area of expertise include melanocytic lesions, adnexal tumors, cutaneous lymphomas and cutaneous inflammatory disorders.

The OPTiM investigators, in an analysis of lesion - level responses, reported that among 2,116 lesions in patients treated with T - VEC, tumor area decreases of ≥ 50 % occurred in 64 % of injected lesions, in 34 % of uninjected nonvisceral lesions, and in 15 % of uninjected visceral lesions.

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

The most clinically desirable biomarkers are those associated with early stage tumor development as they enable surgical removal of lesions before widespread metastasis.

A form of vitamin A, retinyl palmitate is an inactive ingredient in sunscreen that could expedite the growth of skin tumors and lesions.

Primary testicular failure Klinefelter syndrome Cryptorchidism Orchitis Trauma HIV / AIDS Myotonic muscular deficiency Retroperitoneal fibrosis Aging Hypogonadotropic hypogonadism Kallman syndrome Prader - Willi syndrome Idiopathic hypopituitarism Pituitary tumors Suprasellar tumors Hemochromatosis Inflammatory, traumatic, vascular lesions of pituitary and hypothalamus Obesity Severe chronic illnesses Medication Andropause

This tremendous study suggested that pre-cancerous lesions can be used to predict the development of true tumors with 90 - 98 % accuracy.

If you have a pre-existing tumor or Human Growth Hormone deficiency due to a brain lesion, you should be examined routinely for progression or recurrence of the underlying disease process while receiving Human Growth Hormone.

It has been proven that animal protein can literally turn on and off the development of tumors or early lesions that lead to tumors.

Often, medical practitioners can not explain the shrinkage of tumors or the complete abatement of cancerous lesions after traditional treatment has failed.

It is a campaign to encourage veterinarians and pet owners to «Flip the Lip» of their pets and look for abnormalities in the mouth, whether it be periodontal disease, fractured teeth, oral tumors, orthodontic misalignment of teeth, fractured maxillas (upper jaws), fractured mandibles (lower jaws), sympysis separations, especially in cats (left and right mandibular separation), gingivitis, stomatitis and tooth resorptive lesion.

This classification scheme is based on the extent of the tumor, involvement of lymph nodes, and presence of metastatic lesions (TNM system); it includes unclassified tumors and apparently benign dysplasias.

When neurologic symptoms are suggestive of an intracranial lesion, CT (computed tomography) or MRI (magnetic resonance imaging) is necessary to make a diagnosis of a brain tumor.

Histiocytomas are benign skin lesions or tumors (not cancer) that are more common in dogs under 3 years of age.

a. Gangliocytoma — These are rare intracranial tumors (lesions found in the upper part of the skull that protects the brain) that are mostly found in adult dogs.

Description — Lesions of the melanocytes and melanoblasts are relatively common skin tumors in the dog.