Sentences with phrase «tumor mass»

Cancer stem - like cells (CSC) are a minor population of tumor mass and considered to have abilities of tumor initiation, differentiation, and chemoresistance (1).

It is generally believed that a series of mutations in multiple genes are needed for cancer cells to become metastatic; however, recent cancer stem cell theory, which still remains as a hypothesis, predicts that metastatic tumor cells are, by definition, cancer stem cells and that these cells may exist in tumor mass even at an early stage.

As fast growing tumor mass lacks a functioning lymphatic system, clearance of these nanoparticles is limited and further enhances the accumulation.

This abnormal and poorly regulated vessel generation (i.e. angiogenesis) results in vessel walls with large pores (40 nm to 1 um); these leaky vessels allow relatively large nanoparticles to extravasate into tumor masses.

«They can cross different fiber tracts in the brain to reach tumor cells that have migrated away from the main tumor mass.

Many biomarkers are available for estimating tumor mass, but a possibly more important aspect of a tumor's pathology is how aggressive it is and how fast it is growing.

Thus, in a panel of breast cancer samples, we identified tumor cells that did not form part of the bulk tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer cell invasion.

In contrast, the same type of vaccine expressing E7 fused to herpes simplex virus (HSV)-1 glycoprotein D (gD), an antagonist of the coinhibitory B - and T - lymphocyte attenuator (BTLA) / CD160 - herpes virus entry mediator (HVEM) pathways, stimulates potent E7 - specific CD8 (+) T - cell responses, which can be augmented by repeated vaccination, resulting in initial regression of even large tumor masses in all mice with sustained regression in more than half of them.

In this fashion, they derive a signal from the tumor cells proportional to tumor mass which arises spontaneously in vivo in the accurate setting of the lung and from the accurate genetic lesions found in human non-small cell lung cancer (NSCLC).

Application of doubly engineered neural stem cells proves to be a specific and highly effective method of removing remnant tumor mass after surgery

«Our data support a model of chemoresistance in which two modes of evolution, adaptive and acquired, were operating to establish chemo - resistant tumor mass,» said Navin.

«As tumor mass grows rapidly, a network of blood vessels needs to expand quickly to accommodate tumor cells» need for oxygen and nutrient.

Other cancer patients who have not lost their appetites and are eating normally might be tried on one gram of cesium three times daily with observation for signs of recovery (receding tumor masses).

While surgery to remove the main tumor mass can be done, it is not possible to then locate the tumor cells that get away and this ultimately leads to a nearly universal tumor regrowth.»

The treatment reduced the tumor mass substantially.

«Treg cells are concentrated in areas of low oxygen, conditions that are typically found at the center of a tumor mass or in inflamed tissue.

She even found evidence that the devils» immune systems were occasionally performing this interferon - gamma trick themselves: In some instances, tumor cells near the edge of the tumor, in close proximity to white blood cells, showed MHC antigens that cells farther within the tumor mass lacked.

In two cases, he was able to see a single green - glowing cell and watch it divide and ultimately become a tumor mass.

«Radioimmunotherapy not only worked against these cancers but, in addition, the radioactivity was confined entirely to the tumor masses, leaving healthy tissues undamaged,» said senior study co-author Ekaterina Dadachova, an associate professor of nuclear medicine and of microbiology and immunology at Einstein.

«So we hoped that by injecting antibodies hitched to isotopes into the blood that they'd be carried deep into the tumor mass and would latch onto these now - exposed antigens.

«Another model is punctuated evolution in which CNAs are acquired in short bursts of crisis, followed by stable clonal expansion that form the tumor mass.

Researchers found the gene therapy approach had stronger results when used in combination with either depletion of immunosuppressive cells from the tumor mass or with immune checkpoint blockade.

In cancer, Myc levels and its power becomes overwhelming and the cells start to divide wildly and refuse to die, leading to rapid growth of a tumor mass.

Our technology spares the patient from unnecessary exposure to chemotherapy, and can be used safely because the active agents are confined within a tumor mass.»

Selectivity of the therapeutic approach is achieved by producing an enzyme called E. coli purine nucleoside phosphorylase (PNP) directly within tumor cells and using the enzyme to generate novel chemotherapy in the tumor mass itself.

The mAb bound to the amyloid and initiated an Fc - mediated cellular inflammatory response that led to rapid reduction in the tumor masses.

From the perspective of the surgeon, they are challenging lesions because they possess an impressive vascular supply often buried deep within the tumor mass or opposite the surgeon's trajectory.

Treatment of malignant glioma using gene transfer modalities typically consists of surgical debulking of the tumor mass followed by the administration of the viral vectors into the brain tissue surrounding the tumor cavity.

Tumor sections from mice treated with HB1.F3.Ad - H2IgG and HB1.F3.Lenti - H2IgG also showed patches of green cobblestone patterns throughout the tumor mass.

The presence of NSCs within the tumor mass was confirmed by detection of v - myc DNA using nested PCR.

Intravenously - injected parental and transduced HB1.F3 NSCs were detected within the tumor mass of each treated animal by immunohistochemistry.

Initially, it was not known if intravesical therapy would be of benefit in dogs because TCC in dogs would be deeper in the bladder wall, and tumor masses would often be larger than those treated in humans.