In a study presented in the featured clinical investigation article of the November issue of The Journal of Nuclear Medicine, they used 18F - fluorodeoxyglucose (FDG) PET / CT imaging to show that the amount of cell - free tumor DNA circulating in the bloodstream correlates
with tumor metabolism (linked to cancer aggressiveness), not tumor burden (amount of cancer in the body).
Studying mice implanted with human cervical cancer cells, the investigators wiped out many of the animals» tumors with a combination of radiation and three drugs that
target tumor metabolism.
It has been proposed that the ketogenic diet may be a useful tool in exploiting the defects
in tumor metabolism, including that of the Warburg Effect.
Effects of a ketogenic diet
on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.
«These results highlight that 14 -3-3 sigma is an important regulator
of tumor metabolism, and loss of 14 -3-3 sigma expression is critical for cancer metabolic reprogramming.»
Publication: Synergy of Sex Differences in Visceral Fat Measured with CT and
Tumor Metabolism Helps Predict Overall Survival in Patients with Renal Cell Carcinoma.
Wistar scientists led by Maureen Murphy, Ph.D., professor and program leader of the Molecular and Cellular Oncogenesis Program, have found a novel mechanism through which mutant p53 enhances metastasis by
controlling tumor metabolism.
The objective of the study was to shift the prime substrate for energy metabolism from glucose to ketone bodies in order to
disrupt tumor metabolism while maintaining the nutritional status of patients.
This study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with chemotherapy found direct correlation of the amount of cfDNA
with tumor metabolism (based on PET - derived parameters), but not with metabolic tumor volume.
Powell suspects that using glutamine - blocking drugs to
target tumor metabolism could make the environment around a tumor less harsh, slow down its growth and give the immune system a chance to attack the cancer cells.
Dr. Altieri also leads a research program that studies how tumor cells evade programmed cell death and the role of mitochondria, power plant of the cells,
in tumor metabolism.
«Cutting off cervical cancer's fuel supply stymies tumors: Drug combo shuts down
tumor metabolism, mouse study shows.»
In addition, while cfDNA correlated with
tumor metabolism, no association was found with circulating tumor cells (CTCs).
«New insights into
the tumor metabolism: Medical imaging: New biosensor zymonic acid shows changes in pH value.»