Sentences with phrase «tumor metastasis»
"Tumor metastasis" refers to the spread of cancer cells from the original tumor to other parts of the body. It occurs when cancer cells break away from the primary tumor, enter the bloodstream or lymphatic system, and form new tumors in other organs or tissues. It is a serious stage of cancer that can make the disease more difficult to treat. Full definition
Used in models of murine and human tumors, these compounds turned out to be very efficient at blocking the migration of tumor cells and preventing the spontaneous formation of human tumor metastasis in mice!
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Research Paper Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1 / NF - κB pathway in hepatocellular carcinoma Hui Wang, Linhui Liang, Qiongzhu Dong, Lin Huan, Jia He, Botai Li, Chen Yang, Haojie Jin, Lin Wei, Chengtao Yu, Fangyu Zhao, Jinjun Li, Ming Yao, Wenxin Qin, Lunxiu Qin, Xianghuo He Theranostics 2018; 8 (10): 2814 - 2829.
Bernhard Mlecnik and coleagues examin the impact of tumor - intrinsic, microenvironmental, and immunological factors on tumor metastasis in colorectal cancer patients.
The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.
«Cancer: Treatment that prevents tumor metastasis identified in animal study.»
It has been known for decades that warfarin, the most widely used anticoagulant worldwide, reduces tumor metastasis in model systems.
They detected the presence of an enzyme that can induce tumor metastasis, MMP - 2 (matrix metalloproteinase - 2) in mice with cancer.
Analysis of liver tumor samples from patients showed that NRF2 expression correlated with tumor metastasis.
Yoon says the presence of these cells could be a marker for tumor growth and metastasis. Because tumors often metastasize along lymph ducts and into lymph nodes, studying this type of cells could lead to new targets for blocking tumor metastasis.
She anticipates that her research will lead to a better understanding the role of CCR7 (+) breast tumor metastasis to the lymph nodes, and how oncologists treat these tumors.
Upregulation of CXCR4 is essential for HER2 - mediated tumor metastasis.
The joint team, which included both medical and psychological researchers from UCLA, the University of Texas, The University of Iowa and the U.S. National Cancer Institute, analyzed data which explains how the nervous system, and in particular the sympathetic nervous system (SNS), plays a major part in tumor metastasis when the body is under chronic stress.
Research Paper Targeting intracellular MMPs efficiently inhibits tumor metastasis and angiogenesis Yaqi Lv, Xiangmei Zhao, Lidan Zhu, Sijia Li, Qingqing Xiao, Wei He, Lifang Yin Theranostics 2018; 8 (10): 2830 - 2845.
This could mean that the approach can also prevent tumor metastasis, the most threatening aspect of cancer.
The work by Professor Pierre Sonveaux's team, at Université catholique de Louvain's Institute of Experimental and Clinical Research (IREC), succeeded in pinpointing a family of pharmaceutical compounds whose action prevents the appearance of tumor metastasis.
To further understand the effect of miR - 7 and KLF4 on tumor metastasis, we examined the transmigrating ability of CSCs of 231BrM through brain endothelial cells that were originated from mouse brain blood vessel.
The lungs are a very common site for tumor metastasis.
«Our results have potential to lead to development of a new line of therapy for modifying the association properties of these two cell types, especially in osteoporosis and tumor metastasis in bones.»
Tumor metastasis is a leading cause of patient morbidity and mortality, and no treatments are currently available that specifically target metastasis formation.
The researchers also report that radiation sensitivity may be dependent on the anatomic location of the tumor metastasis.
Cheng and colleagues did experiments using human cells and identified hnRNPM's role in controlling the processes linked to tumor metastasis.
«Now we're investigating how the protein works in order to be able to develop a drug that could prevent tumor metastasis.»
Tumor metastasis is the primary cause of mortality in cancer patients and remains the major challenge for cancer therapy.
Even in disease, tumor metastasis, cells get around.
The discovery of cells» ultra-sensitivity for mechanical property of their environment is crucial to understanding basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion — basic physiological processes that underlie embryo development, tumor metastasis, wound healing and many other aspects of human health and disease.
Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.
Despite this clinical importance, the exact pathologic process of tumor metastasis is as yet poorly understood, and deciphering the exact molecular mechanism of this process is of paramount importance to identify specific therapeutic targets for this devastating disease.
Studies are ongoing to define the role of the integrin expression or lack thereof on the tumor cells alone, on cells within the host microenvironment alone, or the contribution on both the tumor cells and within the host microenvironment in tumor metastasis.
Directed cell migration; tumor metastasis; primary cilia; synthetic chemical biology; technology development
The SDF - 1 / CXCR4 axis is gaining significant attention mainly due to its important roles in pathological processes, such as HIV entry, tumor metastasis, cell trafficking in autoimmune diseases and inflammatory conditions [10].
These models are used for both basic and translational research, including studies to investigate the role of tumor initiating cells in tumor relapse, tumor metastasis and therapy resistance.
Some monocytes are pro-tumoral, and other monocyte subsets are anti-tumoral, as we have shown that nonclassical monocytes prevent tumor metastasis.
Cell biologist Dr. Jonathan Cooper and his team are working to pinpoint how cells rearrange their inner scaffolding when they travel through the body — cell migration is a key part of both normal development and tumor metastasis.
Molecular motors have major roles in cell proliferation, cell migration and tumor metastasis.
Large and small animal nuclear medicine is available and is a subspecialty of radiology in which radioisotopes (compounds containing radioactive forms of atoms) are put into the body to evaluate organ function or localize bone disease such as stress fractures or tumor metastasis.