Sentences with phrase «tumor metastasis in»

Bernhard Mlecnik and coleagues examin the impact of tumor - intrinsic, microenvironmental, and immunological factors on tumor metastasis in colorectal cancer patients.

It has been known for decades that warfarin, the most widely used anticoagulant worldwide, reduces tumor metastasis in model systems.

Not exact matches

According to Irving Weissman of the Stanford University School of Medicine in Palo Alto, California: «We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis.»

Aside from the feat of answering the longstanding question of how the lymph system arises, understanding how it forms and develops can provide important insights into disease, from metastasis to the abnormal accumulation of lymph fluids, particularly in the wake of surgery to remove cancerous tumors.

But when their functioning is altered, as the UCL researchers observed in tumor cells, the mitochondria can promote cell migration, thus leading to the formation of metastasis.

The discovery of a treatment capable of blocking the mechanism responsible for the formation of metastasis and the existence of a family of promising compounds, is encouragement for their future assessment in a clinical study that aims to validate a preventive treatment against tumor metastasis.

This is one of the first research studies to highlight the importance of the location of the metastasis as well as the location of the original primary tumor, in predicting response to radiation therapy.

Metastasis, the process that allows some cancer cells to break off from their tumor of origin and take root in a different tissue, is the most common reason people die from cancer.

Looking to target a key pathway in order to interfere with the processes that lead to tumor spread, a research team led by Irwin H. Gelman, Ph.D., of Roswell Park Cancer Institute (RPCI) has identified a new suppressor of cancer metastasis that may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors.

«How melanoma tumors form: Team identifies drugs that halt skin cancer metastasis in lab tests.»

MDSCs are immune cells originating from bone marrow stem cells that possess strong immunosuppressive abilities and are known to play a role in tumor formation and metastasis.

«This study has provided strong evidence demonstrating that the molecular signature of metastasis exists prominently in the primary tumor,» says Mary Hendrix, a cancer researcher at the University of Iowa in Iowa City.

In recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumorIn recent years, atypical protein kinase C signaling has been found in the tissue invasion and metastasis of multiple tumorin the tissue invasion and metastasis of multiple tumors.

Runx2 has been linked to bone metastasis in several solid tumors, though researchers did not analyze the solid tumors for expression of bone - related genes.

Last fall, Bergö's group reported that ingestion of extra antioxidants drove the metastasis of melanoma in a mouse model, though they didn't have any effect on the primary tumor.

With these in vitro test methods, the KU researchers have shown that anti-CD44s antibody can reduce pancreatic cancer cell growth, metastasis and ability of the tumors to recur after radiation therapy.

Part of the cytoskeleton, vimentin gives flexibility and structure to the cell, but it is also a marker of epithelial - mesenchymal transition (EMT), which is considered a crucial event for metastasis in epithelial tumors.

In addition to potentially improving screening tests, the team believes their approach may someday help doctors control CTC - induced metastasis, which the researchers say can be far more lethal than the original tumor.

Their study, in the journal Oncotarget, is the most extensive analysis to date of gene expression's role in ccRCC tumor growth and metastasis.

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

One application is the prognosis of the melanoma: the authors show in tumor biopsies that the amount of RAB7 in a cutaneous tumor defines the risk of developing metastasis.

In an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissuIn an article titled, «Allergen Induced Pulmonary Inflammation Enhances Mammary Tumor Growth and Metastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in thMetastasis: Role of CH13L1,» featured on the cover of the current issue of the Journal of Leukocyte Biology, this new research suggests inflammation raises the level of a known biomarker of cancer, called «chitinase -3-like-1» or «CHI3L1,» in the inflamed tissue, which leads to increased metastasis and faster cancer growth in that tissuin the inflamed tissue, which leads to increased metastasis and faster cancer growth in thmetastasis and faster cancer growth in that tissuin that tissue.

This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.

Cheng and colleagues did experiments using human cells and identified hnRNPM's role in controlling the processes linked to tumor metastasis.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.

Investigators found that NPTX2 was expressed in all stages of kidney cancer, especially metastasis, which suggests it plays an important role in tumor development and progression.

«Now we're investigating how the protein works in order to be able to develop a drug that could prevent tumor metastasis.»

«However, IL6 - secreting tumors could be laying the groundwork for metastasis much earlier than surgery occurs in a patient,» he said.

The work also reinforces the importance of finding tumor cell clusters in the blood as a mechanism of detecting cancer metastasis earlier.

So making cells in the primary tumor softer might be a way to prevent metastasis,» he said.

When the protein is present, these cells that start out round and stuck together in a pattern resembling cobblestones become irregularly shaped and tend to detach from the tumor site in an uncoordinated way — hallmarks of metastasis.

The study also indicated that genomic diversity may also have useful clinical applications for predicting tumor invasion, metastasis and poor survival in patients.

«In the future, our models should provide robust tools to screen for therapies that impact tumor dormancy and metastasis, and should also provide a platform to solve other biological mysteries that underlie dormancy.»

By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new therapies against metastasis, the researchers say in the May Nature Reviews Cancer.

«STAT3 is the primary marker that is used today to ascertain malignancy, tumor aggression and metastasis in ovarian cancer.»

«The result was an extensive inhibition of tumor growth and prevention of metastasis to the lung in HER2 - positive animal models of breast cancer,» notes Navasona Krishnan, Ph.D., a postdoctoral investigator in the Tonks lab who performed many of the experiments and is lead author on the paper reporting the results.

By identifying the cause of this metastasis — which often happens quickly in lung cancer and results in a bleak survival rate — Salk scientists are able to explain why some tumors are more prone to spreading than others.

So that's pretty good because metastasis is what kills you in cancer, not the primary tumor.

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

Tumor metastasis is the primary cause of mortality in cancer patients and remains the major challenge for cancer therapy.

Metastasis (the spread of cancer from its primary site to other places in the body) to the ovaries can result in Krukenberg tumors.

«We found that many more mice developed tumors when given the cells that we had engineered to have these stem cell characteristics, and they had a much higher incidence of metastasis in the lungs,» Kilian said.

In a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilIn a four - year study conducted on the mouse model in advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin advanced breast cancer metastasis in the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye's anterior chamber, Petty and colleagues found that the new nanoparticle not only killed tumor cells in the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kilin the eye, but also extended the survival of experimental mice bearing 4T1 tumors, a cell line that is extremely difficult to kill.

Metastasis is the process in which cells from a primary tumor break - off, enter the blood stream and create new tumors elsewhere in the body.

This allows cancer cells to break off from tumors, spread throughout the body (in blood or other fluid) and form new tumors at distant sites — a process called metastasis.

It is not easy to determine whether metastasis began early or late in the development of the primary tumor or whether individual metastatic sites were seeded directly from the original tumor or from an intermediate site.

The authors note that there are two different models of metastasis — one in which an advanced primary tumor disseminates metastatic cells late in its development, which would predict little genetic difference between primary and metastatic cells, and another in which metastasis occurs early in tumor development, which would predict significant genetic differences in metastatic cells that have evolved separately from those in the primary tumor.