The company showed how they first defined A2A as the receptor
required for mediating the effect of adenosine on immune cells within the
tumor microenvironment and reported the characterization of a novel immuno - oncology - dedicated adenosine receptor 2A antagonist that functions in the high adenosine concentration found in
tumors.
Through its various targets, MMP1 promotes not only
tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from
tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts
required for bone destruction and enhanced
tumor growth in the bone
microenvironment (32).
Here, we uncovered a role for the ABL kinases in promoting breast cancer bone metastasis through the regulation of distinct pathways
required for
tumor colonization and survival in the bone
microenvironment.