Sentences with phrase «tumor models»

The size difference between tumor and healthy circulating DNA was initially discovered in animal tumor models created by inducing tumors with human cancer cells.

In a joint trial, the team then tested the treatment in a further tumor model which mimics the clinical situation of the brain tumor patient even better.

EOS100850 promotes anti-tumor efficacy in mouse tumor models in combination with several immune - checkpoint inhibitors, retains high potency in the presence of elevated intra-tumoral adenosine concentrations, and is non-brain penetrant.

«Indeed, in a second tumor model of metastatic breast cancer, we demonstrated that mice treated with the EphA2 - targeting paclitaxel conjugate presented nearly no lung metastases, while a large numbers of lesions were observed in both untreated mice and in mice treated with just paclitaxel.»

EOS200271 has demonstrated anti-tumor activity in multiple preclinical tumor models in monotherapy and in combination with immune checkpoint inhibitors.

«We report much higher therapeutic efficacy in preclinical brain tumor models using the combination of both therapies, leading to an increase in median survival,» Lowenstein says.

Studies are focused on the pre-clinical development and design of more effective therapeutic approaches to cancer using mouse tumor model systems.

Another key finding was observing the inhibitor effect on tumor models with a gene PTEN deficiency as a biomarker — of huge interest because PTEN, a tumor suppressor, is known to be defective in as many as half of all advanced solid tumor cancers.

Using tumor models for both astrocytoma and oligodendroglioma, which are very similar to human tumors, they could show that one and the same cell type, called oligodendrocyte precursor cells, could give rise to both tumor forms.

Case Western Reserve University School of Medicine Stress signaling inhibitors potentiate genotoxin - induced apoptosis in a human colon tumor model

Dr. Shanker's pioneering studies in murine tumor models identified that tumor - infiltrating CD8T cells provide a necessary «help» to dormant intratumoral natural killer (NK) cells in eliciting their antitumor effector function.

Zebrafish tumor models provide a unique discovery platform for in vivo drug screens, imaging and genetics.

Over 170 carefully curated, well - characterized patient - derived xenograft tumor models are available for use in your facility, or use Horizon's comprehensive preclinical in vivo efficacy service.

«It would be great to see this in other tumor models.»

«Since it is the proteins that interact directly with drugs, the strength of studying proteomics in patient - derived tumor models is the ability to test drug treatment in the mice,» Ding said.

Our research shows that Tumor Treating Fields have an antimitotic effect in more than 18 solid tumor types in culture and in eight in vivo tumor models.

It complements traditional tumor biomarkers and is applicable to many tumor models.

«To my great surprise, even injecting 10 million activated T cells specific to the P1A antigen did not affect tumor growth in this induced tumor model,» says Van den Eynde.

The next step for the researchers is to demonstrate the viability of this approach to the production and delivery of an anticancer molecule in a whole tumor model system.

In a variety of tumor mouse models, including antibody - resistant tumor models, the antibody - IFN therapy was more effective than antibody therapy alone.

[That kind of research] can travel down several different mechanistic routes,» this respondent says, «i.e., angiogenesis, breakdown of extracellular matrix, gene activation, induction of molecules involved — it can use different models — implanting tumors, using different tumor models, in vivo, in vitro, etc.» The combination of a manifestly important goal with manifestly interesting, feasible approaches is the foundation of the research plan.

Ongoing studies from the Discher lab are focused on finding that sweet spot with additional tumor models, as well as on how to engineer macrophages for longer - lasting effect.

They further investigated this phenotype in a skin tumor model system, provided by Maria Sibilia from the Institute for Cancer Research of the Medical University of Vienna, and found that deactivating HDAC1 actually accelerates tumor development, while HDAC2 deactivation has no effect.

In the sensitive tumor models, the ability of anti — cytotoxic T lymphocyte — associated protein 4 or anti — programmed cell death 1 therapy to increase vessel perfusion strongly correlated with its antitumor efficacy.

A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor models.

Engineered silk fibroin protein 3D matrices for in vitro tumor model.

In our study, we demonstrated that VPA administration in tumor models maintained cytolytic activity of donor T cells while inhibiting the proinflammatory function of Th1 and Th17 cells and, thereby, separated GVHD and the GVL effect.

The approach is to use clinically relevant tumor models such as patient - derived xenografts (PDXs), as well as humanized and immunocompetent transgenic tumor - bearing mice to design rational combinations of novel and emerging cancer therapies, including tumor - targeting and immune - stimulating therapies, to ultimately improve treatment outcomes for cancer patients.

This 8 - week study using a rat tumor model showed that oral HMB attenuated the cachexic weight loss caused by the tumor, resulted in decreased tumor weight, and improved glucose and glycogen metabolism.

22) Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly - Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, DePinho RA, Kemp CJ, Varmus HE, Hanash SM (2011) Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.

In a new paper in Science Translational Medicine, the U-M team describes how they developed a novel brain tumor model in mice.

When an animal tumor model was injected with both the nanoparticle and the light - sensitive genetically engineered immune cells, the near - infrared laser beam caused calcium channels to open, which boosted an immune response to aid the killing of cancer cells.

ADCC / ADCP - enabling isotypes of a-TIGIT surrogate Ab show potent monotherapy efficacy in murine tumor models that correlates to increased T cell activation and reduced Treg infiltration of tumors.

Research in the laboratory will combine sequencing platforms with zebrafish tumor models to identify new genes or pathways that drive relapse with the goal of identifying nodes to target with personalized medicines in children with relapsed cancer.

«This finding led to the identification of CFI - 400945, a selective and orally active inhibitor of PLK4, which was shown to have significant antitumor activity as a single agent in a variety of preclinical tumor models.»

Agonist reagents that stimulate OX40 also have great potential therapeutically for vaccination, as shown by a number of studies in tumor models or of responses to viruses where the immune response can be boosted dramatically to aid protection.

«The effective immune response didn't happen in every tumor model we tested, so we still need to figure out exactly what triggered the tumor shrinkage and how to predict which tumors will shrink in response to virotherapy,» said Leddon, who is also working toward her medical and doctoral degrees at the University of Cincinnati.

«And while the tumor model we're now studying doesn't present targets for new drugs, if we can discover the mechanism controlling that model, it may yield therapeutic drug targets.»

Brudno et al. designed a drug - delivery device that can be refilled noninvasively and tested it in a mouse tumor model.

The next step, he added, is to prove the applicability of photoacoustic imaging in tumor models and ultimately in patients.

However, it was unclear at this stage in their research if this was a species - specific finding limited to animal tumor models or if this was a biologic phenomenon that may also be present in cancer patients.

This commentary also points out that in order to obtain effective treatment outcome with the peptide, it is important to consider the biological variation from patient to patient and one tumor model to another in obtaining success by iRGD treatment, as shown in the UCLA led study.

«We demonstrated that the co-administration of the iRGD peptide with the particles can enhance the effectiveness of pancreatic cancer treatment in the tumor model, leading to increased tumor shrinkage, disappearance of metastases and enhanced animal survival» said Meng, an adjunct assistant professor of nanomedicine.