Sentences with phrase «tumor mutation burden»

Patients with both high tumor mutation burden and high PDL - 1 positive status had a 75 percent response rate compared with a 16 percent response rate to immunotherapy among patients with low mutation burden and low PDL - 1.

«The good news is that we discovered that a subset of patients who had both high tumor mutation burden and high PDL - 1 positive status did experience a significant benefit from immunotherapy,» says Carbone.

«This study is an important step toward understanding the impact of tumor mutation burden and PDL - 1 in immunotherapy response.

Not exact matches

«In this study we've shown five distinct ways — by quantifying tumor burden, identifying disease subtype, cataloging mutations, predicting transformation and providing early warnings of recurrence — that circulating tumor DNA can yield potentially clinically useful information,» said Diehn.

In one report, a patient with an L576P KIT mutation in whom imatinib therapy had previously failed experienced marked reduction in tumor burden in response to dasatinib treatment.

The «mutational burden,» or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond...