Sentences with phrase «tumor necrosis»
"Tumor necrosis" refers to the death of tumor cells. When a tumor grows, it needs a blood supply to survive. However, if the tumor grows too quickly, it can outgrow its blood supply, which leads to the cells in the center of the tumor dying. This process is called tumor necrosis. Full definition
We have initiated studies regarding the hypothesis that the benzamides and nicotinamides could inhibit the production of tumor necrosis factor alpha (TNFalpha) and the inflammatory response as well as induce apoptosis via inhibition of NF - kappaB.
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They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.
The molecule, called Takinib, works on a cell - signaling protein called tumor necrosis factor alpha, or TNF - alpha, which is a major contributor to tissue inflammation.
Zinc has an important role in inhibiting tumor necrosis factor (TNF)(Flieger et al. 1989), which has been implicated in the pathophysiology of AIDS, including wasting (Beutler and Cerami 1987).
Rheumatoid arthritis patients who use tumor necrosis factor inhibitors (called Anti-TNFs) to control their disease - related inflammation also have a decreased risk for heart attacks, according to research findings presented this week at the American College of Rheumatology Annual Meeting in San Diego.
Activation of nuclear factor κ - light - chain - enhancer of activated B cells (NFκB) proceeds through multiple pathways involving tumor necrosis factor receptor 1 (TNF - R1) and pathogen - recognition receptors, such as Toll - like receptors (TLRs)(Orlowski and Baldwin, 2002; Madrid and Baldwin, 2003; Hayden and Ghosh, 2004) and nucleotide - binding oligomerization domain - containing protein 2 (NOD2), an intracellular pattern - recognition receptor.
«The rate of tumor necrosis due to 3BP treatment seems to exceed all known cytostatic drugs,» they wrote.
The second gene, TNFRSF6B, encodes a receptor related to those that bind tumor necrosis factor (TNF)-- a key chemical signal for triggering inflammation in IBD as well as in patients with other autoimmune disorders such as rheumatoid arthritis and psoriasis.
In contrast, men have greater tumor necrosis factor - alpha, homocysteine and uric acid levels as well as higher coronary artery calcium score than women.
In 2012, Dr. Krolewski and his team made a very important discovery when they found a link between tumor necrosis factor receptor 1 (TNFR1) and declining renal function in type 1 and type 2 diabetes.
In particular, fetal cells made high amounts of arginase - 2, an enzyme that breaks down L - arginine, a key ingredient in the production of a key messenger named tumor necrosis factor alpha (TNF - alpha).
Research Focus: My main interest is to study the role of Tumor Necrosis Super Family (TNFSF) members in mucosal immunity.
«These results are significant, since tumor necrosis — or death — in response to therapy is also used as the measure of an effective chemotherapeutic,» Meyers said.
Kontoyiannis D., Boulougouris G., Manoloukos M., Armaka M., Apostolaki M., Pizarro T., Kotlyarov A., Forster I., Flavell R., Gaestel M., Tsichlis P., Cominelli F., Kollias G., 2002, «Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor - induced Crohn's - like inflammatory bowel disease», JEM, 196, 1563 - 74.
In contrast, we observed that ABL kinases protected breast cancer cells from TRAIL [tumor necrosis factor (TNF)-- related apoptosis - inducing ligand]-- induced cell death (Fig. 4, G to I).
I am currently working with Zika virus and how it affects the T cell response and T cell signaling through tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in specific mouse model systems.
Goyal RK, Lin Y, Schultz KR, Ferrell RE, Kim Y, Fairfull L, Livote E, Yanik G, Atlas M. Tumor necrosis factor - alpha gene polymorphisms are associated with severity of acute graft - versus - host disease following matched unrelated donor bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium study.
Effects of polyphenolic compounds on tumor necrosis factor - α (TNF - α)- induced changes of adipokines and oxidative stress in 3T3 - L1 adipocytes.
Bananas may have bad rep compared to darker & less caloric fruits, but even eating a ripe banana, especially half of it, especially especially if you're not diabetic isn't completely wrong and futile — good guy tumor necrosis factor ftw
CsA and tacrolimus have also been reported to reduce eosinophil production, block mast cell degranulation and suppress tumor necrosis factor cells.
In addition, cancer often stimulates the liver to make tumor necrosis factor (TNF).
Specifically A20 appears to call off a substance known as tumor necrosis factor (TNF).
The study involved injecting into joints an AAV that carried a gene coding for a protein that inhibits a proinflammatory cytokine called tumor necrosis factor α (TNF - α).
Reactivation of HBV may occur with chemotherapy, organ and tissue transplantation, High dose corticosteroids, and biologicals targeting tumor necrosis factor - alpha (TNF - α), Anti-TNF medications are used in treating rheumatic diseases, such as rheumatoid arthritis, digestive conditions that include Crohn's and colitis, and dermatologic conditions, such as psoriasis.
Interferons Inhibit Tumor Necrosis Factor --LCB- alpha -RCB-- mediated Matrix Metalloproteinase - 9 Activation via Interferon Regulatory Factor - 1 Binding Competition with NF --LCB- kappa -RCB- B
Another study found a reduction in the inflammatory biomarkers human soluble tumor necrosis factor - α, interleukin - 6, C - reactive protein, and soluble intercellular adhesion molecule - 1 (61).
Researchers in Sweden sought to determine if use of tumor necrosis factor inhibitor drugs to treat RA would result in a reduced risk of acute coronary syndrome (commonly called ACS), defined as a diagnosis of a heart attack or unstable angina (the worsening or increasing cardiac symptoms)
«Using tumor necrosis factor inhibitors decreases risk of heart attacks in rheumatoid arthritis patients.»
A Mayo Clinic study is shedding light on why some rheumatoid arthritis patients respond poorly when treated with tumor necrosis factor inhibitors, part of a class of drugs called biologics.