Sentences with phrase «tumor patient even»

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Other patients had tumors that shrank but didn't disappear, or that remained stable while on — and even after — treatment.

Even before treatment, cancer patients in the study had a small number of infection - and tumor - fighting T cells that target these unusual proteins, the researchers found.

According to Dr. Cripe, the study suggests that some patients could respond to therapy even if their tumors aren't very infectable by the virus, provided their immune systems were stimulated by the viral therapy to attack the tumor cells.

Detecting the presence of tumor estrogen or HER2 receptors with PET scans would enable oncologists to examine all sites of cancer for each patient, choose the appropriate drug treatment more quickly, monitor the tumor for changes that would necessitate a switch to another treatment, and even evaluate how well a drug is hitting its receptor targets.

Most cancer patients would opt for tumor profiling even if the test revealed that they or their families were at risk for other genetic diseases, according to a Yale Cancer Center study.

However, the cancer cells of individual other tumor facets of the same patient survived the treatment and were even able to reproduce much more intensively.

Morrison notes that tumor growth differs even among patients with the same type of cancer.

By injecting T - VEC into the patients» tumors, even those that were located deeper in the body, the researchers were able to transform cold tumors into hot ones, which in turn allowed pembrolizumab to deliver a beneficial enhancement.

«By accurately assessing tumor resection margins intraoperatively with CLI, surgeons may be able to completely clear the cancer with a single operation, thereby reducing the number of breast cancer patients requiring a second, or even third, surgical procedure.

In some cases, patients» tumors develop resistance to Gleevec — either the Abl protein mutates so that the drug can no longer bind to it, or the protein accumulates in such quantities that the drug can't keep up, even at the highest dose.

The patient, a 42 - year - old man, had been suffering from a malignant tumor on his tongue that made it impossible for him to speak, swallow, or even open his mouth.

Patients experienced poor outcomes even when the tumors had been assigned low Gleason grades.

Scientists at Cedars - Sinai have developed a new way to identify which prostate cancer patients are likely to develop aggressive types of the disease even if their tumors at first appear to be lower risk.

Even more nerve - racking for the patients was the fact that typically six weeks would pass before he could assess tumor response.

The paper identified two barriers: a wide variation in EGFRvIII expression in patients and a resistance in the tumor microenvironment, which researchers showed became even more immunosuppressive following CAR T cell infusion.

Even with treatment, most patients live only about a year after diagnosis, and tumors frequently recur.

To their surprise, the mutations that had made their lab - grown cells resistant to ADZ8055 were present in some patients» tumors even before treatment.

Dr Bruix said that the benefits of the drug were evident regardless of the cause or stage of the tumor, but analysis of biomarkers would reveal whether there might be certain sub-groups of patients likely to derive even greater benefit from this treatment.

By modifying a muscle transplant operation, Johns Hopkins surgeons report they are able to restore authentic facial expressions of joy — wide and even smiles — to selected patients with one - sided facial muscle paralysis due to birth defects, stroke, tumors or Bell's palsy.

Historically, medulloblastoma has been treated as a single disease even though researchers at St. Jude and elsewhere showed that patient outcomes vary widely based on their tumor subtype.

But a new study of dogs with tumors — as well as one human cancer patient — reveals that injecting certain bacteria directly into the growths can shrink or even eliminate them.

Friedman notes that, even with the increasing number of drugs targeting specific molecular abnormalities that drive tumor growth, most patients are only treated with one such drug at a time.

«It has long been a question whether we'd even be able to detect sufficiently mutation - reactive T cells in patients with tumors that have low mutational loads.»

By modifying a muscle transplant operation, Johns Hopkins surgeons report they are able to restore authentic facial expressions of joy 3/4 wide and even smiles 3/4 to selected patients with one - sided facial muscle paralysis due to birth defects, stroke, tumors or Bell's palsy.

However, some patients develop tumors even when these genes contain no mutation.

Of the 22 patients whose tumors successfully grafted, six died before data from the mice were available, but in 13 of the remaining 16 cases, there was a positive correlation between mouse and human results.2 In a second study, performed in collaboration with Manuel Hidalgo of the Spanish National Cancer Research Center, the team found that 6 of 13 patients with advanced solid tumors who were treated based on results from personalized PDX mice had partial tumor remissions, even in cases where genetic sequencing of the tumor showed no actionable mutations.3

These drugs also disrupt normal bodily systems and even make the patient more prone to tumor development.

Organs, tissues and even cancer patients» tumors move around all the time,» says Geoffrey Ibbott, Ph.D., professor of Radiation Physics at MD Anderson.

Coukos, who is currently leading an ovarian cancer clinical trial sponsored by CRI's Clinical Accelerator, sought to understand why PD - 1 / PD - L1 immunotherapies are often ineffective for these patients, even though ovarian tumors are often infiltrated by «killer» T cells that recognize tumor - specific neoantigens and express high levels of PD - 1.

His success in studying virus - host interactions inspired him to tackle an even more difficult question: How do tumor cells turn against their hosts and eventually kill the cancer patients.

«Our anaylsis suggests that biomarkers like E-cadherin are even more important than tumor size, tumor grade, the presence of estrogen receptors or the age of the patient.»

At the molecular level, tumors from various patients can often be quite different from each other, even though they belong to the same type of cancer.

Consequently, most patients with advanced disease have died from a local recurrence of their tumor, even after aggressive treatment.

Tumor heterogeneity, i.e., the differences between cells within one tumor, among different tumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future theTumor heterogeneity, i.e., the differences between cells within one tumor, among different tumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future thetumor, among different tumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future thetumor lesions of the same patient, or between patients even if the tumors are of similar genetic signatures, provides major challenges for future therapy.

«We have already received four remote tumor samples and generated two new ROS1 cell lines from patients who never even had to travel to University of Colorado,» says Doebele.

They even found talcum powder particles in the tumors of the ovarian cancer patients they studied.

Such drugs as Zyprexa, which was meant to treat depression or bipolar disorder was found to be causing diabetes in many patients and also led to serious side effects such as pancreatitis, tumors and even death.