Sentences with phrase «tumor progression»

The loss of let - 7, the authors argue, could be seen as one crucial step in this process of tumor progression.

This would be expected to promote tumor progression and could therefore explain the increase in tumors in these mice.

The experiments show that cooperation between different cell clones can be essential for tumor progression.

A mouse study using the ketogenic diet alone significantly decreased blood glucose and slowed tumor progression.

Using melanoma cells and both young and old normal skin cells as a model, the lab is trying to unravel what these changes may be, and how they affect tumor progression.

The mice that were not given antibiotics, however, showed rapid tumor progression.

But questions remained about the timing and course of tumor progression.

Recent active research in miRNA identified a series of this type of molecules that are involved in tumor progression in various tumors as oncogenes and tumor suppressors (8, 9).

«The finding that certain cell signaling lipids change the activity of an oncogenic Ras protein, suggests that we might be able to interfere with tumor progression by inhibiting the enzymes which make the specific cell signaling lipid in cells,» Buck said.

IL - 6 has pleiotropic roles during tumor progression and metastasis that include increased tumor cell survival, expansion of breast cancer stem cells, and resistance to targeted therapies (52).

Tea has been scientifically associated with health benefits such as suppressing tumor progression and decreasing inflammation.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

Sun, H., Wang, Y., Chinnam, M., Zhang, X., Hayward, S.W., Foster, B.A., Nikitin, A.Y., Wills, M., Goodrich, D.W. E2f binding - deficient Rb1 protein suppresses prostate tumor progression in vivo.

Dampening oncogenic KRAS using genetic manipulation in mice inhibited tumor progression despite the presence of other genetic defects.

the role of somatic stem cells in determining tumor progression and metastatic behavior, and control of the stem cell niche by tumor microenvironment

In particular, the goals are to investigate patient epigenetic variation that influences the response to immunotherapy and to use epigenetic therapeutics alone or in combination with immunotherapy to inhibit tumor progression as well as to overcome resistance to immunotherapy.

«Patients with cancer causing tumors of the esophagus had 100 % success rate in preventing tumor progression into the cancerous state when treated for two years with a humic extract solution.»

«In a previous paper we found that another micro RNA, let - 7, drives tumor progression at an earlier stage,» Peter said.

In order to determine whether reduced miR - 192 levels are only a chance side effect of cancer and inflammation or whether they in fact influence tumor progression, the investigators equipped pancreatic cancer cells with additional miR - 192.

Based on their results, the researchers suggest a cause - and - effect relationship: «this suggests that castration does not initiate the development of prostatic carcinoma in the dog, but does favor tumor progression» 5 and also «Our study found that most canine prostate cancers are of ductal / urothelial origin....

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

What is the effect of fluctuating oxygen tension on tumor progression?

Dr. Graupera's team found that either genetic or pharmacological inhibition of only one specific PI3K isoform, called p110α, is enough to induce tumor cell death and compromises vessel growth, which blocks tumor progression and metastasis.

Trefoil factors: tumor progression markers and mitogens via EGFR / MAPK activation in cholangiocarcinoma.

Patients were randomized to receive either nivolumab or a single type of standard chemotherapy until tumor progression was observed.

The overexpression of Runx2 also enhanced secretion of soluble factors that aid tumor progression and metastasis, including cytokines and growth factors.

The trial, conducted in advanced ovarian cancer patients, was a pilot trial aimed primarily at determining safety and feasibility, but there were clear signs that it could be effective: About half of the vaccinated patients showed signs of anti-tumor T - cell responses, and those «responders» tended to live much longer without tumor progression than those who didn't respond.

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

Ben Stanger, MD, PhD, a professor in the division of Gastroenterology, and first author Ravi Maddipati, MD, an instructor in the division of Gastroenterology, say that these results may prove useful in designing better targeted therapies to stop tumor progression and provide an improved non-invasive method for detecting early disease states in this highly lethal cancer.

Stanger and Maddipati tested the hunch that clusters of cells of different genetic makeup were better at establishing secondary tumors and found that a significant fraction of metastases involve seeding by more than one type of tumor cell during the natural course of pancreatic tumor progression.

Verhaak said whether these mutations are markers of good prognosis or actually have a role in thwarting tumor progression is not known.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Stereotactic radiosurgery is an effective and commonly used treatment for brain metastases, but intracranial tumor progression is frequent after SRS alone, primarily because of the development of new metastatic lesions.

Moreover, ROBO1 has previously been shown to suppress cell proliferation, suggesting that this pathway could delay tumor progression.

The heterogeneity of prostate cancer makes it difficult to diagnose and predict tumor progression.

When either JSI - 124 or sialidase were used alone, they either did not have any effect tumor growth or enhanced tumor progression, respectively.

In addition, some CFSs overlap tumor suppressor genes, whose inactivation further fuels tumor progression.

A sensor developed at A * STAR can detect bladder cancer cells and track tumor progression Microelectronic engineers in Singapore have developed and tested sensor technology that can detect an... Read more

A hypoxia - dependent decrease in DNA repair could lead to the accumulation of unrepaired lesions in tumors and contribute to tumor progression [46].

CTC detection under therapy may be the hidden link between tumor progression & thrombosis.

This review examines the historical tumor progression genetic model of laryngeal carcinomas, from dysplasia to invasive carcinoma and the role of infiltrating immune and inflammatory cells as contributors to this process.