Sentences with phrase «tumor progression at»

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Not exact matches

But a late - stage clinical trial called CheckMate - 026 for the drug failed to meet its primary goal of halting cancer progression in advanced, untreated patients whose tumors consisted of at least 5 % PD - L1.

Over the years, many different mathematical models of tumor growth have been proposed, but determining which is most accurate at predicting cancer progression is a challenge.

«If we can identify the point at which tumor cells acquire the characteristics of stem cells, it will be possible to look for ways to interrupt the process and avoid progression of the disease.»

Although BRCA1's role in tumor initiation is well known, the fact that it also seems to be involved in tumor progression comes as a surprise, says Eliot Rosen, a molecular biologist at Georgetown University in Washington, D.C.

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

«You can look at it in terms of tumor biology — our current strategy is to treat and then as long as the tumor responds to any degree, to watch for progression without paying much attention to depth of response.

In their report that has received advance online publication in Nature Nanotechnology, a research team based at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) describes how a nanomedicine that combines photodynamic therapy — the use of light to trigger a chemical reaction — with a molecular therapy drug targeted against common treatment resistance pathways reduced a thousand-fold the dosage of the molecular therapy drug required to suppress tumor progression and metastatic outgrowth in an animal model.

The trial included three groups of patients: those who did not undergo surgery following infusion (three patients who had multi-focal and recurrent tumors not amenable to surgical resection prior to infusion); those who underwent «late surgery» (three patients who had surgery once at either day 34, day 55, or day 104 following infusion); and those who underwent «early surgery» (four patients who had clear symptomatic progression leading to a combined regimen of CART infusion followed by clinically indicated surgery).

Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.

Patients with advanced cancers who took a drug designed to relieve constipation caused by pain killers lived longer and had fewer reports of tumor progression than cancer patients who did not receive the drug, according to results presented Oct. 27 at the 2015 meeting of the American Society of Anesthesiologists in San Diego.

Tumors shrank or disappeared and disease progression was temporarily halted in 15 children with advanced neuroblastoma enrolled in a safety study of an experimental antibody produced at St. Jude Children's Research Hospital.

Once the tumors are established in the mice, the researchers can introduce additional mutations at any time, allowing them to study the influence of each mutation on tumor initiation, progression, and metastasis.

The research could help determine which individuals are at greatest risk of developing lung tumors that may be amenable to a new therapy to inhibit their progression.

«Historically, when treating early lung cancer with radiotherapy, progression at the site of the primary tumor was the most common failure resulting in suffering and death,» said lead study author Robert Timmerman, MD, professor and vice chair of the department of radiation oncology at the University of Texas Southwestern Medical Center in Dallas.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

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Researchers at the Université libre de Bruxelles, ULB define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis.

Dr. Ready said the crossover at progression could have influenced the survival data; in fact, an analysis of six patients who crossed over to sunitinib showed that tumors that had been growing either slowed their growth or shrank following crossover.

A sensor developed at A * STAR can detect bladder cancer cells and track tumor progression Microelectronic engineers in Singapore have developed and tested sensor technology that can detect an... Read more

11/13/2008 How Eating Red Meat Can Spur Cancer Progression Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors.

He noticed that in this region the gene processes were frequently flawed and that a protein known to help the progression and development cancer was produced at abnormally high levels, making the tumors of these patients more resistant to treatment.

Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression.

Since completing the initial paper published Thursday, the team has analyzed 50 more samples from eye fluid of retinoblastoma patients, including those with less aggressive tumors whose eyes were saved, to get a start on determining what factors might be at play in tumor progression.

A disease control rate (DCR) of 64 % (16/25) was observed, including durable tumor growth arrest in patients who had evidence of disease progression at study entry.

«Visualizing how cancer cells interact with a tumor microenvironment that accurately reflects the complex biology of ovarian cancer should help us understand the mechanisms underlying metastatic progression as well as identify new therapeutics that can inhibit this process,» said clinical gynecologic oncologist Ernst Lengyel, MD, PhD, senior author of the study and a professor of obstetrics and gynecology at the University of Chicago.

Identify an alternate paradigm of tumor progression whereby metastases arise from cells that disseminate from the primary site at any stage of primary tumor progression and evolve independent from the primary tumor (i.e., parallel progression models).

Veterinary oncologists working with a program at the University of Pennsylvania are treating mammary tumors in shelter dogs with the hope of learning about the progression of breast cancer in humans.

More often than not, a single dog will have multiple tumors in its 10 mammary glands, each at a different stage of progression.