Sentences with phrase «tumor promoter in»

HIF1 - alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment - specific oncogenesis

«Nobody ever looked for NPTX2 as a potential tumor promoter in kidney cancer or any other cancer, from what we can tell,» says Dr. Radisky.

TPA is a toxic chemical described as «a potent tumor promoter in mouse skin» by the Boston - based firm Cell Signaling Technology.

Not exact matches

These lesions normally remain dormant, but a steady dose of cancer promoters in the diet may override natural defenses against the growth of tumors.

Richard Moriggl and his co-workers have now published in the journal Leukemia how the tumor promoter STAT5 integrates metabolic signals that contribute to oncogenic transformation.

A major discovery from those inquiries was that one player in that rewiring, a protein called ATF2, can switch from its usual tumor - preventive function to become a tumor promoter.

Because DDX3 exhibits tumor suppressor functions, such as a growth - suppressive property and transcriptional activation of the p21waf1 / cip1 promoter, and is inactivated through down - regulation of gene expression or alteration of subcellular localization in tumor cells, all these features together suggest that DDX3 might be a candidate tumor suppressor.

Because DDX3 harbors growth - suppressive ability and transcriptional modulation activity of the p21waf1 / cip1 promoter, in this work we further examined the deregulated expression of DDX3 in tumors by a cancer profiling array and immunohistochemical staining analysis.

The researchers looked exclusively at small segments of DNA called promoters in samples of tumors taken from 308 pancreatic cancer patients.

With the knowledge that the HOXA9 promoter is methylated in stage I tumors, Robles, Lissa, and team used ddPCR technology to analyze HOXA9 promoter methylation in formalin - fixed, paraffin - embedded tumor specimens.

This conundrum appeared to be resolved in 1995 by the finding that p16 function is often inactivated in tumors by promoter hypermethylation (Merlo et al. 1995).

By using a strategy to target DNA methylation directly to the p16 promoter in mice, epigenetic inactivation of p16 function has been demonstrated unequivocally to cause tumor formation (Yu et al. 2015).

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K - ras, c - myc proto - oncogenes in urinary (transitional cell) bladder carcinoma