Sentences with phrase «tumor regression»

Further injections, however, safely drive tumor regression.

A PD -1-specific monocolonal antibody induces frequent tumor regressions in patients with advanced melanoma, renal cancer, lung cancer, and colon cancer with very low rates of toxicity.

Notably, in mice bearing breast cancer cell line - derived tumors, administration of OTSSP167 significantly impaired the growth of basal breast tumors, or even caused tumor regression; by contrast, the growth of luminal tumors were largely unaffected by the treatment (Figure 7E, 7F).

[i] Gutterman JU, Blumenschein GR, Alexanian R, Yap HY, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S. Leukocyte interferon - induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma.

Adding total body irradiation to preparative lymphodepletion chemotherapy prior to the adoptive cell transfer of tumor - infiltrating lymphocytes (TILs) had no effect on tumor regression in patients with metastatic melanoma, according to the results of a study published in the Journal of Clinical Oncology.

[ii][i] Marchand M, Weynants P, Rankin E, Arienti F, Belli F, Parmiani G, Cascinelli N, Bourlond A, Vanwijck R, Humblet Y, Canon J - L, Laurent C, Naeyaert J - M, Plagne R, Deraemaeker R, Knuth A, Jäger E, Brasseur F, Herman J, Coulie PG, Boon T. Tumor regression responses in melanoma patients treated with a peptide encoded by gene MAGE - 3.

In 2010, CRI researchers Drew Pardoll, M.D., Ph.D., Susan Topalian, M.D., and colleagues completed a phase I study showing that a PD -1-specific monoclonal antibody induces frequent tumor regressions in patients with advanced melanoma, renal cancer, lung cancer, and colon cancer with very low rates of toxicity.

More than one - third of patients with metastatic uveal melanoma had objective tumor regression when treated with adoptive transfer of autologous tumor - infiltrating lymphocytes.

Let's see a peer - reviewed paper showing ANY population ANYWHERE living into its 90s and 100s on low - carb, or a low - carb Ornish who reversed CVD or diabetes or cancer and documented the reversal with follow - up angiograms, PSAs, imaging showing tumor regression, etc..

Forty - nine percent of patients treated with selumetinib exhibited tumor regression, compared with none in the chemotherapy group.

«Not only did we find that LIGHT expression promoted tumor regression, upon further study we also identified the specific type of T - cell — CD8 — that was responsible for shrinking the tumor,» Maker said.

In the preclinical study reported in Science Translational Medicine, 50 percent of mice treated with two doses of the vaccine — mice that would have otherwise died from melanoma within about 25 days — showed complete tumor regression.

According to the study, previous research had shown that adoptive cell transfer was capable of mediating a durable tumor regression in patients with metastatic melanoma.

A luminescent marker is also injected, which enables live monitoring of metastasis, tumor regression after treatment, and disease relapse.

These results indicate that active immunization concomitantly with blockade of the immunoinhibitory HVEM - BTLA / CD160 pathways through HSV - 1 gD may result in sustained tumor regression.

Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long - term tumor regression.

Ginger's anti-cancer components work synergistically to make the whole plant responsible for tumor regression.

The findings provide proof of principle that restoring the function of a single tumor suppressor gene can cause tumor regression and suggest future avenues for developing effective cancer treatments.

Adding total body irradiation to chemotherapy prior to the adoptive cell transfer of TILs had no effect on tumor regression in patients with metastatic melanoma.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

He confirmed the anti-tumor potential of OX40 in mice when antibodies that stimulated OX40 activity expanded the T cell population within tumors, and drove tumor regression.

The adenosine A2A receptor is the main adenosine receptor expressed on immune cells, which promote anti-tumor immune responses, leading to tumor regression when inhibited with an adenosine A2A antagonist.

Pioppino mushrooms (Agrocybe aegerita) induced tumor regression, reversing cancer in lab mice.

In the mice that received GD2 CAR - T cells, the DIPG tumors were undetectable after 14 days, while mice receiving the control treatment had no tumor regression.

Yet as recently as 2005, doctors at Dartmouth and Harvard universities concluded that Coley may have been right that some infections, particularly those caused by Streptococcus, might cause tumor regression.

New research by scientists at Dana - Farber Cancer Institute (Dana - Farber) and Brigham and Women's Hospital (BWH) reveals an unexpected mechanism behind these tumor regressions.

A significant amount of scientific data underlines that targeting the adenosine - cancer axis through the A2A receptor can promote anti-tumor immune responses and lead to tumor regression.

A significant amount of scientific data underlines that targeting the adenosine - cancer axis through the A ₂ ₐ receptor can promote anti-tumor immune responses and lead to tumor regression.

Slow down lymphoma growth modestly and show no effect on tumor regression; delay tumor recurrence with activation of p53; enhance tumor regression and inhibit tumor recurrence after alkylating drug therapy.