Sentences with phrase «tumor rejection in»

We observed enhanced tumor rejection in DGKζ - deficient mice and DKO mice relative to WT or Cbl - b — deficient mice.

The decreased tumor size and enhanced tumor rejection in DGKζ - deficient mice indirectly suggests that enhanced Erk signaling may be superior to enhanced NF - κΒ activation in facilitating T cell activity against tumor, especially because DKO mice did not exhibit improved tumor control relative to DGKζ − / − mice.

This did induce an immune response but only led to tumor rejection in one - quarter of the animals.»

Not exact matches

Key studies in mice showed that NF - κB can mediate immune rejection of tumors.

The rejection of the tumor then worked in 80 percent of the test animals.

Ectopic expression of retinoic acid early inducible - 1 gene (RAE - 1) permits natural killer cell - mediated rejection of a MHC class I - bearing tumor in vivo.

Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin - 2 receptor alpha) monoclonal antibody.

In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivIn their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivin vitro and mediated tumor allograft rejection in vivin vivo.

James P. Allison and Matthew Krummel demonstrate that a monoclonal antibody directed against the CTLA - 4 molecule in a mouse model of melanoma could result in the rejection of tumors and that this rejection also resulted in immunity to a second exposure to tumor cells.

Thus, in a single experiment, the authors demonstrated that (1) CD4 + and CD8 + T - cells were the mediators of immune system rejection of transplanted tumor cells, and (2) d42m1 escape tumors develop from T - cell - dependent selection favoring cells without the spectrin - B2 antigen.

IDO1 has been implicated in immune modulation through its ability to limit T cell function and engage mechanisms of immune tolerance, and as such preventing tumor rejection.

Moreover, knock in animal models for syngeneic studies and allowing us to isolate transgenic armed effector cells are developed in order to show proof of concept for the diverse applicability of our modular targeting systems including for tumor diseases, autoimmune diseases, GvHD, transplantation / rejection as well as viral infections.

This single - celled algae also increases the activity of Natural Killer (NK) cells, a type of white blood cell that plays a major role in host rejection of tumors.