Sentences with phrase «tumor samples»
"Tumor samples" refer to small pieces or samples of abnormal tissue found in a tumor, which is an abnormal mass of cells. These samples are collected for analysis and examination in medical laboratories to understand the characteristics, behavior, and potential treatment options for the tumor. Full definition
Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.
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The ambitious plan was to create a new shared resource of tumor samples with attached patient information.
We will do the rest — we'll contact your doctors and hospitals to obtain copies of your medical records and a portion of your stored tumor samples.
In order to test whether the method is suitable for use in clinical routine diagnostics, the scientists analyzed more than 1,100 additional tumor samples.
Some tumors carry genetic mutations and the actual tumor sample is submitted to the laboratory to identify the mutation and the type of tumor.
Some of these studies may be looking for blood or tumor samples directly from owners so you may want to check out this information.
All of these hallmarks — reduced SIRT6, increased Lin28b and reduced let - 7 expression — were found in tumor samples from patients who died more quickly.
To confirm this observation at the protein level, we analyzed primary tumors samples for MELK expression.
The results of a study of more than 100 human tumor samples show that the tumors expressing a high level of CCR3 present more frequent local dissemination.
The team looked at tumor samples taken from 314 patients diagnosed with DCIS.
«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»
(B) ABL2 mRNA abundance in 61 normal samples compared with 532 invasive breast tumor samples in the TCGA database.
To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).
Lee and colleagues collected tumor samples as part of the AVAST - M trial, which compared bevacizumab and placebo in 1,343 patients with high - risk resected stage II / III melanoma.
Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer.
A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.
The latter, presented by Eric Lander of the Broad Institute in Cambridge, Massachusetts, would systematically sequence tumor samples for mutations involved in cancer to speed up the search for new drugs and diagnostics.
Zhang et al performed whole - genome sequencing on tumor samples and matched normals from 12 children with ETP - ALL.
«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.
Researchers examined tumor samples for various genetic causes of EGFR resistance, including T790M, the most common secondary mutation.
In a study whose findings were published in the journal Cell on Thursday, May 5, researchers at the University of São Paulo's Ribeirão Preto Medical School (FMRP - USP) in Brazil and collaborators in several other countries describe a method that objectively measures the degree of similarity between tumor samples and pluripotent stem cells (cells that can differentiate into nearly any type of tissue in the body).
Diagnosis is made after examining a small tumor sample under a microscope.
Where once it was possible to test tumor samples for only one mutation or genomic rearrangement at a time, NGS technology now enables testing for multiple gene mutations in multiple samples simultaneously.
Researchers searched through all thyroid cancer tumor samples in the hospital's possession from the study period for patients who lived in at - risk regions Dauphin, York, eastern Cumberland, Lancaster and western Lebanon counties.
Eight institutions from the United States and Europe contributed tumor samples to the project.
Caris, under the guidance of Baker, provided the tissue and ran the molecular profiling on solid tumor samples collected from across the United States.
Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.
«This broad implication is in contrast to a more traditional vaccine - based approach, which requires a specialist to surgically remove tumor samples from a patient's body then create a personalized vaccine approach for one specific patient.»
The test, called ProsignaTM and manufactured by NanoString Technologies, comes with a machine and kit, so patients» tumor samples do not have to be sent to a single laboratory for analysis.
«We used biopsied tumor samples from DIPG patients to create models in the lab, which we studied and then used to test a novel, targeted approach to treating the tumor.
To craft a powerful immunotherapy treatment, immunologist Steven Rosenberg and his colleagues at the National Cancer Institute (NCI) in Bethesda, Maryland, obtained tumor samples from 13 patients with metastatic melanoma.
«The end game is to take the guesswork out of chemotherapy, with a clinical test that will assess dozens of drugs and drug combinations against tumor samples from each patient.»
Finally, Hannibal's tumor sample made it to Breen's lab at NC State, where a genomic test and pathology report confirmed a diagnosis of T cell lymphoma.
Two dozen experienced pathologists from seven countries and four continents independently reviewed 268 tumor samples diagnosed as EFVPTC from 13 institutions.
Ependymomas also occur in adults, but in the study, none of the adult tumor samples had reduced H3K27me3.
This study analyzed preserved tumor samples from 43 prostate cancer patients who later received radiation therapy after rising PSA levels were detected following a radical prostatectomy.
Here, Teresa Davoli and colleagues examined data from over 5,000 tumor samples representing 12 cancer types from The Cancer Genome Atlas (TCGA) project.
Now researchers have taken a small step in that direction: They've deciphered a genetic «signature» that, in several tumor samples, appears to predict whether a cancer will spread.
«Any researcher interested in quantifying stemness indices for their own tumor samples can apply the method and contribute to its validation,» he said.
To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.
In the findings, published in the Journal of Clinical Investigation on December 11, researchers reveal that co-expression of cell surface receptor integrin αvβ3 and transcription factor Slug — a master regulator of a cell's ability to self - renew and differentiate — identifies rare stem - like cells in patient - derived tumor samples that are associated with metastasis.
Working on the same tumor samples, Feinberg's team looked for other kinds of changes — specifically in the so - called epigenome, the array of reversible chemical and structural changes to DNA and the proteins around which it is wrapped.
«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.
Analysis of liver tumor samples from patients showed that NRF2 expression correlated with tumor metastasis.