As Fiebig found in his early work,
tumor samples do not always successfully graft onto the mice.
The test, called ProsignaTM and manufactured by NanoString Technologies, comes with a machine and kit, so patients»
tumor samples do not have to be sent to a single laboratory for analysis.
Not exact matches
She and her colleagues sequenced genomic DNA in the
tumor samples but
did not find any new driver gene mutations in the metastatic
samples compared to the primary
tumor samples, said McDonald, who completed clinical training under Iacobuzio - Donahue at Johns Hopkins.
The team also compared the animals» responses to the therapy's effects in laboratory cell
samples and found that in vitro studies
did not predict how well the viral therapy and immune response would fight
tumor cells in vivo.
Using
tumor samples from a patient, they
do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.
The researchers analyzed the
samples using immunohistochemistry and RNA sequencing to study the changes in the
tumor immune microenvironment of patients who received and
did not receive chemotherapy, and changes before and after chemotherapy.
The model, called COXEN (CO-eXpression gENe analysis), sorts through the massive genetic data of thousands of
tumor samples to discover differences between
tumors that responded and
tumors that
did not.
A multicenter team of researchers reports that a full genomic analysis of
tumor samples from a small number of people who died of pancreatic cancer suggests that chemical changes to DNA that
do not affect the DNA sequence itself yet control how it operates confer survival advantages on subsets of pancreatic cancer cells.
They found that the levels of two specific tRNAs were significantly higher in metastatic cells and metastatic
tumors than in primary
tumors that
did not metastasize or healthy
samples.
«With liquid biopsies, we don't have to wait for
tumor growth to get a DNA
sample,» says Dr. Vasmatzis.
Thus, in a panel of breast cancer
samples, we identified
tumor cells that
did not form part of the bulk
tumor mass, but instead were interspersed within the adjacent stroma — as if forming the forefront of cancer cell invasion.
To help the patient, and also make some advances in tech development, Jones and his colleagues
did whole - genome and RNA - Seq of the
tumor samples and matched normals.
The concern is that not only
does aspiration cytology only
sample a very small amount of a given lymph node, but that it is difficult to ensure that we have correctly predicted the optimal lymph node to
sample for any given mast cell
tumor.
There is still more to
do, and owners of Golden Retrievers diagnosed with lymphoma or hemangiosarcoma can support this important research by donating a
tumor sample (www.modianolab.org or www.breenlab.org) or a blood
sample (www.dogdna.org)
A tissue
sample would be taken at
tumor removal surgery (if that's
done) or when the dog is euthanized.