Sentences with phrase «tumor samples finds»

WASHINGTON (May 17, 2017)-- A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

Not exact matches

She and her colleagues sequenced genomic DNA in the tumor samples but did not find any new driver gene mutations in the metastatic samples compared to the primary tumor samples, said McDonald, who completed clinical training under Iacobuzio - Donahue at Johns Hopkins.

However, many studies have found the inconsistency of EGFR mutation status in plasma DNA samples as compared to tumor tissue DNA samples.

The team also compared the animals» responses to the therapy's effects in laboratory cell samples and found that in vitro studies did not predict how well the viral therapy and immune response would fight tumor cells in vivo.

The finding, reported by a Stand Up to Cancer - Prostate Cancer Foundation Dream Team in the May 21 edition of the journal Cell, is based on an analysis of tumor samples from 150 men with metastatic prostate cancer that no longer responded to standard hormone - blocking therapy.

They analyzed bacterial DNA found in breast tissue samples from 58 women who were undergoing lumpectomies or mastectomies for either benign or cancerous tumors, as well as from 23 healthy women who had undergone breast reductions or enhancements.

They found that the levels of two specific tRNAs were significantly higher in metastatic cells and metastatic tumors than in primary tumors that did not metastasize or healthy samples.

«And we found all three types of «gain - of - function» mutations in the estrogen receptor gene ESR1 in the tumor samples.»

The researchers were able to replicate this finding by comparing the healthy thyroid tissues in GTEx to 500 samples taken from thyroid tumors, compiled by The Cancer Genome Atlas, and giving support to the extensive impact of FOXE1 on cellular state.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

«Our findings show that high - intensity circulating tumor DNA sequencing is possible and may provide invaluable information for clinical decision - making, potentially without any need for tumor tissue samples,» said lead study author Pedram Razavi, MD, PhD, a medical oncologist and instructor in medicine at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY.

After sequencing the tumor samples, the authors found that the JAK2 gene was more frequently amplified in chemotherapy - treated TNBC than in tumors before treatment.

Researchers have found a group of circulating tumor cells in prostate cancer patient blood samples which are linked to the spread of the disease, according to new research presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

In collaboration with Dr. Omer Iqbal, from the Department of Pathology, they are analyzing the genetics and biology of tumor samples to find how they differ from samples of tumors not linked to radiation.

Notably, the researchers found that, using their methods, highly reactive TILs could be obtained from some 90 % of the ovarian cancer patients whose tumor samples they examined.

«Based on our findings, the next phase will be to measure exosomes and exomeres in plasma samples to help predict organs that may be targeted for metastasis during tumor progression,» said Dr. Lyden.

As Fiebig found in his early work, tumor samples do not always successfully graft onto the mice.

Perhaps the most intriguing — and contentious — finding of the paper (as highlighted by GT's In Sequence magazine and Keith Robison on Omics Omics) was that few of the somatic mutations in the metastasis were detected in the primary tumor sample from 9 years earlier.

Another collaboration was unfolding among the cancer geneticists, sequencing experts, clinical researchers, and surgical oncologists at Johns Hopkins, MD Anderson, and Baylor College of Medicine to study 32 pairs of head and neck tumor and normal tissue samples by whole - exome sequencing and validate the findings in an additional 88 samples.

Further, for each plasmid in the kit, the transcript most commonly found across all TCGA tumor samples is represented, making the results of any such study as clinically relevant as possible.

There is considerable interest in finding CNAs that affect the same chromosomal region in multiple tumor samples.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

Outside retinoblastoma experts say they're excited about the finding because they've never been able to grab samples of the tumors they treat without removing the eye.

For example, proteins related to angiogenesis, the process through which new blood vessels form to ensure supply of oxygen and nutrients to a tissue such as a tumor, are found to be clearly associated to clinical outcome in HPV - positive samples.

When the researchers compared average cytokine levels in CFS patients versus the healthy control samples, they found that only 2 of the 51 substances they tested for were significantly different: One, called tumor growth factor beta, was higher in CFS patients, while the other, called resistin, was lower.

Closely monitoring several markers of cell damage (including creatine kinase, lactate dehydrogenase, prostaglandin - E and tumor necrosis factor - alpha) in their sample of 18 male athletes (who used 20 grams of creatine monohydrate per day for five days, mixed with 60 grams of maltodextrine), the researchers found levels of these markers were reduced after the race, compared to 16 control subjects who took only the maltodextrine.

What they found: Denosumab delayed and prevented tumor growth in the tissue samples and the mice.

The study found that it's now feasible in dogs to collect a tumor sample and perform molecular profiling in less than a week's time, a clinically practical window.

They also found that just over half the tumors samples analyzed carry genetic mutations that could be targeted by therapies that are already on the market.