Sentences with phrase «tumor site»

A key challenge for scientists is how to help nanoparticles travel to and be retained at tumor sites.

The mouth is the fourth most common tumor site in dogs.

Eligible patients included those with stage IV disease, spread to six or fewer sites including the primary tumor site, and who responded at least partially to first - line / induction chemotherapy.

Recent improvements in tumor detection and precise image - guided radiation therapy, however, have made simultaneous treatment of multiple tumor sites with radiation feasible.

They also discovered that the protected tumor sites lacked one component of the immune system.

One drug attacks cancer cells; the other inhibits cancer cell formation and the growth of blood vessels at tumor sites.

This can be challenging because there may be multiple tumors and / or the primary tumor site may be difficult to determine.

The chip would allow the filtering of cancer cells from a blood sample, which would be an easier way to harvest cancer cells, rather than the current method of taking them from tumor sites in the body.

The new research, which is detailed in Biomaterials, showed that slow - release peptide gels could continuously deliver immunotherapy drugs to tumor sites for long periods of time.

Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

Intravenously - delivered NSCs preferentially migrate to primary and metastatic tumor sites within and outside the CNS.

The unique tumor - tropic properties of neural stem cells (NSCs) may provide the means to significantly improve antibody distribution within metastatic tumor sites throughout the body [2], [3], [4], [5], [6].

As in mice, the particles homed in on tumor sites, thanks to a coating of the drug pamidronate, which preferentially binds to degraded sites in bone.

Wong and his lab want to see if edelfosine could be incorporated into future clinical research focused on other tumor sites such as lung, ovarian and pancreatic cancers.

With a focus on high - tech radiotherapy such as image guided radiotherapy (IGRT), stereotactic body radiotherapy (SBRT), brachytherapy and radiobiologic modulation of tumor response, I have had the chance to use precise radiotherapy to treat variety of tumor sites such as genitourinary, gynecologic, soft tissue sarcoma, gastrointestinal, head and neck cancer and metastatic disease.

They cross the blood - brain / blood - tumor barrier, and accumulate within brain tumor sites, where they target oncogenes, regulate cell growth and differentiation, reduce tumor burden and prolong survival in our mouse models.»

A new study shows that a 70 - year - old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumor site, overcoming a significant hurdle of targeted drug delivery, according to a team of researchers led by Houston Methodist.

Now a research team has developed a simple assay that can reveal the evolutionary relationships among various tumor sites within a patient, information that may someday help with treatment planning.

In some individuals there were significant genetic differences between tumor sites, suggesting early metastatic spread; in others, there was little difference between a primary tumor and its metastases.

«This combination of features means that the drugs can not only attack the main tumor site, but are more likely to find and attach themselves to tumor cells circulating in the bloodstream — essentially attacking new tumors before they start,» says Quanyin Hu, lead author of the paper and a Ph.D. student in the joint biomedical engineering program.

Melanoma is more likely than other skin cancers to spread beyond the initial tumor site to other organs, but all the patients had localized disease.

11/19/2007 New Technology to Treat Breast Cancer Shows Promise in Early Application Physicians at the Rebecca and John Moores UCSD Cancer Center will present the initial outcomes of their use of a new device that delivers radiation therapy to a specific tumor site at the annual meeting of the Radiological Society of North America (R...

A Tao brush resembles a pipe cleaner, Fader said, and can be used to collect tissue samples closer to potential tumor sites.

This metastasis occurs even if there is no evidence of secondary tumor sites at the time of surgery.

For this research, Ga - 68 DOTATOC, short for gallium - 68 1,4,7,10 - tetraazacyclododecane - N, N ′, N ′ ′, N ′ ′ ′ - tetraacetic acid - d - Phe1 - Tyr3 - octreotide, was administered to 36 patients with metastatic NET and unknown primary tumor site.

When researchers injected fresh breast cancer cells in the side opposite the original tumor site, the disease didn't recur in any of the mice, as the cancer was rejected by the immune system's memory.

The CART - meso cells trafficked to tumor sites in three of four patients with available tumor samples.

Stephan realized that he could load anti-tumor T cells — immune cells specially engineered to recognize and destroy cancers — into dissolving polymer scaffolds and place them directly at tumor sites.

TCGA is still worth it, he says, but «the return on the investment [for this cancer] is less than for other tumor sites.»

Proton therapy delivers high radiation doses directly to the brain tumor site, with no damage to nearby healthy tissue.

Even in nanomedicine, which is one of the best new methods for delivering drugs to a tumor, only about one percent of a dose of nanoparticles will successfully arrive at the intended tumor site, while the rest are filtered out by the immune cells of the liver and spleen.

We believe that disrupting this niche will delay or prevent metastatic spread, and more importantly, protect tumor sites from hemorrhage, which is the most common lethal event in this disease.

Previous studies have demonstrated that HB1.F3 cells, a clonal, well - characterized human NSC line [8], can effectively express and deliver a variety of therapeutic agents to primary and metastatic tumor sites, including metastases to the brain [2], [4], [5], [6], [9].

A magnetic oxide material incorporated into the nanoparticles could allow the assemblies to be directed to a tumor site by an external magnet, and could also support diagnostic imaging.

«This technique creates a steady, sustained release of antibodies directly into the tumor site; it is an efficient approach with enhanced retention of anti-PD-1 antibodies in the tumor microenvironment,» says Zhen Gu, an assistant professor in the biomedical engineering program and senior author of the paper.

«This combinational treatment also was well tolerated and enhanced the number of CD8 T cells at the tumor site.

«First, the anti-PD-1 antibodies are usually injected into the bloodstream, so they can not target the tumor site effectively.

Immune cells, which were built to respond to inflammatory signals, will be naturally attracted to the tumor site.

If this is true, we might be able to identify these subsets and target them before these cells leave their original tumor sites and invade distant organs,» says Prof. Alon.

The problem previous researchers couldn't overcome was how to keep the herpes viruses at the tumor site long enough to work.

«Because the particles are so small, if they happen to reach the tumor site they have a chance of penetrating through the blood vessel wall because the vasculature of tumors is usually leaky.»

Tumor cells circulating within a patient's bloodstream can carry cancer from a primary tumor site to distant sites of the body, spreading the disease.

These particles congregate at tumor sites, where MMPs cleave hundreds of peptides, which accumulate in the kidneys and are excreted in the urine.

This dramatic expansion is fueled by the excitement surrounding the company's Transmembrane Carrier System, a technology that aims to treat cancer by delivering therapeutic compounds through the bloodstream to tumor sites.

«Currently, the antibodies can not target the tumor site effectively.

Bone metastases happen when cancer cells travel from the primary tumor site to the bone, establishing a new cancer location.

In the era of precision medicine, targeting the mutations driving cancer growth, rather than the tumor site itself, continues to be a successful approach for some patients.

The team of medical and engineering researchers at The Ohio State University previously determined that modifying a single gene to reduce this protein's level in breast cancer cells lowered the cells» ability to migrate away from the tumor site.