Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of abnormal
tumor stem cell differentiation (9).
Zaidi HA, Kosztowski T, DiMeco F, Quiñones - Hinojosa A. Origins and clinical implications of the brain
tumor stem cell hypothesis.
However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative
tumor stem cell populations by the cell - sorting approach.
The term «
tumor stem cell» only reflects the fact that this is a tumor cell with capacities similar to normal stem cells, such as the capability to maintain itself indefinitely.
A major new insight is the realization that different tumors of the same type may rely on entirely different
tumor stem cell populations.
A common misconception about the research field is that
a tumor stem cell is actually a subtype of stem cell and that hence, cancer derives from stem cells.
A lot of effort in
tumor stem cell research has always been directed to finding a so - called marker, a molecule whose presence on a cell reliably identifies it as a cancer stem cell.
If we can boost the immune system and allow microglia to do their job and control brain
tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»
Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking
tumor stem cells, were nothing of the kind.
Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called
tumor stem cells, but
tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.
In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in
the tumor the stem cells appeared.
Context, tissue plasticity, and cancer: are
tumor stem cells also regulated by the microenvironment?
In fact, it is thought that common chemotherapies, targeting the fast - dividing cells, leave the relatively slow - dividing
tumor stem cells unharmed and thus pave the way for an eventual relapse.
«
Tumor stem cells can be considered to be the replicative engine of the malignant process, in other words, the cellular pool that continuously nourishes tumor growth.
Nevertheless, the field is — also due to the lack of standard conditions for important methods — currently struggling with many issues such as the challenge of developing a clear definition of what
tumor stem cells actually are and how they can be identified.
The working hypothesis of the Herlyn lab is that tumor - maintenance cells (
tumor stem cells) are central to dormancy due to their non-proliferation or very slow turnover and their non-responsiveness to growth signals.
Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain
tumor stem cells
Not exact matches
Cauliflower contains sulforaphane, a sulfur compound that is shown to kill cancer
stem cells and slow
tumor growth.
Cauliflower is high in sulforaphane, a sulphur compound that has been shown to kill cancer
stem cells, thereby slowing
tumor growth and support liver detoxification pathways.
Sulforaphane (a sulphur compound) is a key compound in broccoli which has the ability to kill cancer
stem cells, which slows
tumor growth.
When a
tumor is treated with chemo, the
tumor may disappear but some cancer
stem cells have the ability to survive, and they have the potential to regenerate the original
tumor and spread the cancer elsewhere.
In 2010, researchers from the University of Michigan Comprehensive Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer
stem cells in mice and in lab cultures, and it also prevented the growth of new
tumor cells.
«An index measures similarity between cancer
cells and pluripotent
stem cells: The new methodology measures
tumor aggressiveness and the risk of relapse, helping doctors plan treatment.»
An immune response, triggered by foreign neural
stem cells, could actually help attack
tumors, says Evan Snyder, a
stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using
stem cells to attack
tumors.
But the next big question was whether these
cells could home in on
tumors in lab dishes, and in animals, like neural
stem cells.
Mouse
tumors injected directly with the reprogrammed
stem cells shrank 20 - to 50-fold in 24 — 28 days compared with nontreated mice.
But that gives scientists a secret weapon — if they can harness
stem cells» natural ability to «home» toward
tumor cells, the
stem cells could be manipulated to deliver cancer - killing drugs precisely where they are needed.
In human
cells and in mice, the virus infected and killed the
stem cells that become a glioblastoma, an aggressive brain
tumor, but left healthy brain
cells alone.
Studies suggest that
stem cells sustain deadly
tumors in the brain — and that aiming at these insidious culprits could lead to a cure
Cancer
cells which arise due to genetic mutations are just such
cells, and there are studies which suggest that microchimeric
cells may stimulate the immune system to
stem the growth of
tumors.
A route used by
tumor cells to spread could be exploited to make
stem cells for regenerative medicine and cancer therapies
By analysing the early steps that precede
tumor formation, Alexandra Van Keymeulen and colleagues found that expression of oncogenic Pik3ca reactivates a multilineage differentiation program in adult
stem cells that resembles to an immature embryonic state.
They discovered that the chemicals and radiation used to kill
tumor cells damage the
stem cell reservoir in the hippocampus and nearly halt the formation of new neurons in both children and adults.
Cancer
stem cells can reproduce themselves through a process called self - renewal and sustain the growth of a
tumor.
«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer
cells and thus can only reduce the bulk of the
tumor,» said Jamieson, who is also deputy director of the Sanford
Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Cell Clinical Center, director of the CIRM Alpha
Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Hea
Cell Clinic at UC San Diego and director of
stem cell research at Moores Cancer Center at UC San Diego Hea
stem cell research at Moores Cancer Center at UC San Diego Hea
cell research at Moores Cancer Center at UC San Diego Health.
Also limiting the use of therapeutic
stem cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source of cancer risk when haphazard, unlimited
cell multiplication results in the abnormal tissue growth seen in
tumors.
Small populations of adult
stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out
cells and tissues, and evidence is growing that rare cancer
stem cells are responsible for the uncontrolled growth of some malignant
tumors, including glioblastoma.
In the context of the collaboration between the Gates Center for
Stem Cell Biology and the CU Cancer Center this was the second clinical trial we offered to our patients with the specific intent to eliminate the CSCs in their
tumors.»
«Herpes - loaded
stem cells used to kill brain
tumors.»
Further preclinical work will be needed to use the herpes - loaded
stem cells for breast, lung and skin cancer
tumors that metastasize to the brain.
«Our work strongly supports that cancer
stem cells are the main source of growth in these
tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper.
«Just as normal
cells with the same genome differentiate into many different
cell types, a single
tumor characterized by specific genetic mutations can contain many different types of
cells —
stem - like and more differentiated
cells — with the difference being rooted in their epigenetic information.
Several studies have used
cell - surface markers — proteins found on the outer membranes of
tumor cells — to identify glioblastoma
stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within
tumor cells.
Their analysis of more than 4,000 individual
tumor cells, the largest effort to date in brain
tumors, finds three developmental categories of cancer
cells — one resembling neural
stem cells and two characterized by sets of genes indicting paths towards differentiation.
A study analyzing brain
tumor genomics on a single -
cell level has found evidence that cancer
stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.
The investigators report that trapping virus - loaded
stem cells in a gel and applying them to
tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain
tumor in human adults and also the most difficult to treat.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma
stem cells from more differentiated
tumor cells and to suggest potential therapies targeting those factors.
Published in Molecular Neurobiology, the study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime - Morawek, Lecturer in
Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor c
Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human
tumor cellscells.
Cancer
stem cells will need to be identified and treated in a different manner than the bulk
tumor.»
In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma
stem cells capable of
tumor propagation than in differentiated
tumor cells.