Sentences with phrase «tumor stem cells»

A major new insight is the realization that different tumors of the same type may rely on entirely different tumor stem cell populations.

Zaidi HA, Kosztowski T, DiMeco F, Quiñones - Hinojosa A. Origins and clinical implications of the brain tumor stem cell hypothesis.

A lot of effort in tumor stem cell research has always been directed to finding a so - called marker, a molecule whose presence on a cell reliably identifies it as a cancer stem cell.

Since then, additional CSC markers have been proposed and studied to isolate putative tumor stem cell populations.

Many of us believe that a number of anti-cancer therapies fail to succeed because we are still unable to target tumor stem cells.

Brain Tumor Action Week helps to fund cutting - edge research, such as the effort to target and eliminate tumor stem cells — seed cells that can regenerate a tumor again and again.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

Targeting solid tumor stem cells The Disease Team III grant to Dr. Dennis Slamon and Dr. Zev Wainberg and their US - Canadian collaborative team will support the first in human clinical trial scheduled to open in early 2014.

In fact, it is thought that common chemotherapies, targeting the fast - dividing cells, leave the relatively slow - dividing tumor stem cells unharmed and thus pave the way for an eventual relapse.

Nevertheless, the field is — also due to the lack of standard conditions for important methods — currently struggling with many issues such as the challenge of developing a clear definition of what tumor stem cells actually are and how they can be identified.

Although many posit that tumor cell heterogeneity is of a genetic basis associated with inherent high genomic instability in tumor cells, the heterogeneous cellular composition in tumors has also been hypothesized, early on, to be the consequence of abnormal tumor stem cell differentiation (9).

If we can boost the immune system and allow microglia to do their job and control brain tumor stem cells, it would be like removing the seed from the soil — stopping the tumor growth before it starts to get out of control.»

However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative tumor stem cell populations by the cell - sorting approach.

«The tumor stem cells kill the organoid in two weeks.»

Another is that the transplanted bits of tumor act nothing like cancers in actual human brains, Fine and colleagues reported in 2006: Real - life glioblastomas grow and spread and resist treatment because they contain what are called tumor stem cells, but tumor stem cells don't grow well in the lab, so they don't get transplanted into those mouse brains.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

Tumor stem cells are mistaken for the «cell of origin» of a tumor.

A common misconception about the research field is that a tumor stem cell is actually a subtype of stem cell and that hence, cancer derives from stem cells.

«Tumor stem cells can be considered to be the replicative engine of the malignant process, in other words, the cellular pool that continuously nourishes tumor growth.

The term «tumor stem cell» only reflects the fact that this is a tumor cell with capacities similar to normal stem cells, such as the capability to maintain itself indefinitely.

The working hypothesis of the Herlyn lab is that tumor - maintenance cells (tumor stem cells) are central to dormancy due to their non-proliferation or very slow turnover and their non-responsiveness to growth signals.

The discovery of tumor stem cells in a range of cancers has created opportunities for researchers to identify these rare cells in both solid tumors and hematologic cancers, as well as to investigate the role of these cells at different stages of disease.

Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells