Sentences with phrase «tumor subclones»

These «tumor subclones» are often very relevant as the tumor evolves (especially during treatment).

Not exact matches

But tumors from patients with distant metastases to the lung and liver showed massive epigenetic changes that mapped to large, blocklike segments of the genome, both in the distant metastases themselves and in the section, or «subclone,» of the primary tumors they came from.

The mammary tumors frequently contained two distinct subclones — one produced Wnt1 while the other did not.

Thus, two subclones of the tumor in AML35 both acquired activating mutations of IDH2 at the same residue but by different mutations.

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.

Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single - Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.