Sentences with phrase «tumor subpopulations»

Herlyn's working hypothesis is that defined tumor subpopulations are central to dormancy and drug resistance due to their slow turnover and their non-responsiveness to growth signals.

A clustering analysis of mutant allele frequencies suggested that there were four clones (tumor subpopulations) in the primary tumor defined by distinct sets of mutations.

The de novo platinum resistance of this tumor subpopulation can explain why these cancers consistently reappear after first - line platinum - based chemotherapy,» the study states.

Not exact matches

«These results provide an unprecedented window into the cellular dynamics of tumor evolution and suggest that interactions between subpopulations of tumor cell types contribute to metastatic progression from initial tumors,» Stanger said.

A T - cell marker panel that can identify subsets of tumor - associated T - cells allows scientists to identify and target subpopulations of T - cells playing unique roles in the immune response against a tumor.

Together, these results suggested that EMT contributes to the establishment of a small cell subpopulation in malignant tumors; this population is then capable of driving the regeneration of the tumor, even when the bulk tumor cell mass is destroyed by therapeutic regimens.

Hence, BH3 mimetics might represent an attractive approach of eliminating resistant subpopulations of cancer cells, thereby targeting both tumor cell invasion and cancer relapse.

Within tumors, there exists a subpopulation called the «cancer stem cells» (CSCs).

The subpopulation that failed to produce Wnt1 contributed to tumor growth with a mutation in a gene called HRas, which regulates cell division.

In addition, understanding the genetic differences between the subpopulations could lead to novel treatment strategies aimed at eliminating tumor cell communities.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Growth curves of primary tumors generated from the parental cell lines and cycling hypoxia - selected subpopulations.

Subpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for canSubpopulations of breast cancer cells sometimes cooperate to aid tumor growth, according to Penn State College of Medicine researchers, who believe that understanding the relationship between cancer subpopulations could lead to new targets for cansubpopulations could lead to new targets for cancer treatment.

Limiting dilution assays were performed to evaluate the tumor - initiating and metastatic ability of this subpopulation.

The evidence suggests that a relatively minor subpopulation of tumor cells (clone 4) survived chemotherapy and arose to become the dominant clone at relapse.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Collectively, our results support the idea that a stem - like subpopulation in the tumor could expand selectively in response to changes in the microenvironment.

The long - term goal is to develop strategies for two therapies, one for eliminating the bulk of the tumor, the other for small subpopulations that escape all major therapeutic strategies.

The lab is delineating tumor dormancy in melanoma and characterizing subpopulations of cells with a major focus on slow - proliferating cells that have high proliferation potential hypothesizing that these cells are critical for dormancy and therapy resistance.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression.