Sentences with phrase «tumor subtypes»
Tumor subtypes refer to different categories or types of tumors that can occur in the body. These subtypes are distinguished by specific characteristics, such as their location, appearance, behavior, or genetic makeup. Identifying tumor subtypes helps doctors understand the nature of the tumor better and determine the most appropriate treatment options. Full definition
«Parsing the molecular details of tumor subtypes and resistance mechanism allows us to better define the therapeutic landscape as we pursue translational research,» said Resnick.
sciencedaily.com
«Biology of childhood brain tumor subtypes offers clues to precision treatments: Researchers reveal differences among gene fusions in low - grade pediatric brain tumors.»
The teams at MD Anderson's and Center for Co-Clinical Trials are using the PILOT platform to investigate novel vulnerabilities across tumor subtypes with the aim of identifying targets for therapeutic development.
In addition, the study, led by investigators in The Cancer Genome Atlas (TCGA) Research Network, revealed four novel tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast, ovarian, and colorectal cancers.
Different tumor subtypes can include glandular, which include the mammary glands, as well as squamous, which are very rare and involve epithelial cells that line the inside of the breast.
«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.
Researchers have identified the cells that likely give rise to the brain tumor subtype Group 4 medulloblastoma.
The authors undertook a higher - resolution survey of these associations within tumor subtypes, finding known driver events, such as amplifications of MYC, CCND1, ERBB2, and CCNE1 and deletions of PTEN and MDM2, as well as putative but suggestive events involving MDM1, MDM4, CDK3, CDK4, PI4KB, NCOR1, and others.
Although grouping of patients by subtype is an important first step toward developing personalized treatments, limited tumor subtyping resources are currently available.
Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping Xiaofeng Dai, Hongye Cheng, Zhonghu Bai, Jia Li Journal of Cancer 2017; 8:3131 - 3141
[6] Breast cancers after Hodgkin lymphoma were enriched for the basal and human epidermal growth factor receptor 2 (HER2)- enriched tumor subtypes (50 % overall) and were found to have significantly higher expression of the Ki - 67 proliferation marker compared with controls, as well as a profile of chromosomal instability.
«Knowing the cell of origin of cancer cells can provide insight into tumor subtypes and possibly diagnostic and therapeutic benefit,» says JAX Assistant Professor Jennifer Trowbridge, Ph.D., the lead author of the study published on July 11 in Nature Communications.
«Researchers mine the epigenome to identify likely origins of childhood brain tumor subtype.»
«This indicates that therapies for high - grade gliomas should be personalized, that is, based on the tumor subtype instead of applying one treatment to all patients,» he says.
The analysis showed that links between molecular processes in breast cancer tumors and the bloodstream do exist, but that they vary according to the tumor subtype.
«Carefully defining the molecular landscape of these tumor subtypes may guide us in pediatric precision medicine, to better treat children with brain tumors,» said Payal Jain, PhD, a postdoctoral researcher at Children's Hospital of Philadelphia (CHOP).
«If our findings are confirmed by additional studies, they may open doors to the development of targeted therapies against the tumor subtypes more likely to affect African Americans and potentially help reduce racial disparities in breast cancer.»
Historically, medulloblastoma has been treated as a single disease even though researchers at St. Jude and elsewhere showed that patient outcomes vary widely based on their tumor subtype.
«Each tumor subtype might warrant dedicated clinical trials because of the marked genomic differences between them that are indicative of different drivers of cancer,» said study co-leader Elaine Mardis, Ph.D., co-director of the Genome Institute at Washington University School of Medicine in St. Louis.
The data include demographic characteristics, stage, tumor grade and size, primary treatment, and health insurance status of 102,064 U.S. women, plus their tumor subtypes, hormone receptor (HR) status, and human epidermal growth factor 2 - neu (HER2) status.