Sentences with phrase «tumor suppression mechanism»

Excitingly, our study points out that condensin plays an important role in cellular senescence, a major tumor suppression mechanism.

«In drug development, it's easier to turn that growth function off than it is to switch on the cell's defective tumor suppression mechanism.»

Not exact matches

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Lloyd Trotman Molecular mechanisms of tumor suppression; cancer modeling and treatment; molecular cancer visualization; PTEN regulation

Mechanisms that link tumor suppression and the development of cancer to aging and the major diseases associated with aging

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Understanding molecular mechanisms underlying tumor suppression mediated by the RB1 and TP53 genes

Dr. Matsuzaki has accumulated extensive expertise in T - cell biology and mechanisms of immune suppression in periphery and tumor microenvironments in patients with ovarian cancer.

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.