Sentences with phrase «tumor suppression mediated»

More recently, we elucidated an additional mechanism of tumor suppression mediated by canonical ephrin - induced EphA2 signaling (Figure 1A), which leads to inhibition of the AKT - mTORC1 oncogenic pathway through interplay of EphA2 with a phosphatase that dephosphorylates the AKT serine / threonine kinase.

Understanding molecular mechanisms underlying tumor suppression mediated by the RB1 and TP53 genes

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Isoprenoid - mediated suppression of HMG CoA reductase in tumors was previously correlated to growth arrest; the latter was attenuated by supplemental mevalonate.

It can be proposed that p21 contributes to mediate p53 - dependent tumor suppression in some tumor types, which would include histiocytic sarcomas, hemangiomas, B - cell lymphomas, and lung carcinomas, but not in other tumor types, particularly spontaneous or radiation - induced T - cell lymphomas.

Tumor cell programmed death ligand 1 - mediated T Cell suppression is overcome by coexpression of CD80.

This approach has led to the finding that activated fibroblasts in the tumor stroma mediate immune suppression in several mouse models of cancer, including the autochthonous model of pancreatic ductal adenocarcinoma of the Tuveson lab.

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.