Sentences with phrase «tumor suppressor gene frequently»

However, in the deleted chromosome region, BECN1 is adjacent to BRCA1 (breast cancer 1, early onset), which is a breast cancer tumor suppressor gene frequently mutated in familial breast and ovarian cancers.

Not exact matches

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

P53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.

P21 is closely related to the tumor suppressor gene P53: cancer suppression and enhanced regeneration are frequently found to be opposite sides of the same coin.

These tumor suppressor genes are two of the most frequently altered genes in human cancer, and understanding how they function at the molecular level will both refine our fundamental understanding of this disease and suggest novel therapeutic approaches to treat it.