Sentences with phrase «tumor suppressor gene regulates»

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

The researchers further found that miR - 486 is itself regulated by the tumor - suppressor gene p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional p53.

Among them: some genes believed to be tumor suppressors turned on or became more active, whereas certain disease - promoting ones, including oncogenes (in the so - called RAS family that are implicated in both prostate and breast cancer), were down - regulated or switched off.

P53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.

Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the tumor suppressor gene p53 that is commonly mutated in human prostate cancers.

Mutations in one of these genes, NF1 — a known tumor suppressor gene that regulates the RTK / RAS / RAF pathway — had previously been reported in lung cancer.