Sentences with phrase «tumor suppressor genes»

These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.

Off - target mutations in tumor suppressor genes, for example, can cause cancer.

Researchers have identified a protein that activates the well - known tumor suppressor gene p53 to prevent the division of cells that have damaged DNA.

«Combination therapy strengthens T cells in melanoma pre-clinical study: Findings have implications for treating tumors lacking tumor suppressor gene PTEN.»

After the KRAS mutation was induced by the researchers, other mutations in what are known as tumor suppressor genes developed.

His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.

Dr. Kemp has studied the genetic and molecular basis of cancer for more than 25 years and has been internationally recognized for his pioneering research on tumor suppressor genes.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

When tumor suppressor genes work properly, they «slow down cell division,» repair broken DNA, and trigger programmed cell death.

It must be especially gratifying to Al — the consummate pediatrician, medical geneticist, and cancer biologist — to know that cancer centers throughout the world are routinely performing DNA - based tests of tumor suppressor genes for diagnosis and counseling of patients from cancer - prone families.

Polyploid cells, which carry additional copies of important tumor suppressor genes, are better protected and more resistant to cancer formation because they have these extra copies of the genome,» said Dr. Zhu, who is also an Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern.

«PTEN is one of the most frequently deleted tumor suppressor genes in cancer, so if we can take our finding to the next level and develop a therapeutic around it, it could have wide utility,» said Furnari, who is also a Professor of Pathology at the University of California, San Diego.

The long - term goals of my laboratory are to understand how alterations in the RB1 and TP53 tumor suppressor gene regulatory networks cause cancer.

«Inactive tumor suppressor gene discovered in lung cancer.»

Synthetic lethality - based strategy has been developed to identify therapeutic targets in cancer harboring tumor suppressor gene mutations, as exemplified by the effectiveness of PARP inhibitors in...

Taking into account that it acts as a positive regulator of p21waf1 / cip1 expression and has growth - suppressive ability on liver cancer cells, presumably DDX3 is a candidate tumor suppressor gene in liver.

McGarvey, K. M.; Fahrner, J. A.; Greene, E.; Martens, J.; Jenuwein, T.; Baylin, S. B. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.

Tumor suppressor genes work to keep cancer from developing.

These observations support the notion that BECN1 is a haploid - insufficient tumor suppressor gene and distinguish it from other classic tumor suppressors that require both alleles be inactivated in promoting tumorigenesis.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

However, in the deleted chromosome region, BECN1 is adjacent to BRCA1 (breast cancer 1, early onset), which is a breast cancer tumor suppressor gene frequently mutated in familial breast and ovarian cancers.

«We reasoned that this retained synthetic essential gene might be required for cancer - promoting actions when the cancers lose specific tumor suppressor genes.»

Dr. Lowy's growth - regulation research includes prior studies that established the importance of the RAS gene family in cancer and the main mechanisms by which the NF1 tumor suppressor gene regulates normal cell growth.

Many, if not all, oncogenes and tumor suppressor genes induce metabolic reprogramming in cancer cells through changes in the regulation of enzymes and transporters.

His lab discovered the first oncogene in 1982 and the first tumor suppressor gene in 1986.

Now, researchers studying mice have found one of the most powerful tumor suppressor genes yet — animals lacking it have a startling 50 % chance of developing cancer.

The findings provide proof of principle that restoring the function of a single tumor suppressor gene can cause tumor regression and suggest future avenues for developing effective cancer treatments.

African - Americans, on the other hand, experienced heightened mutations in BCL7A, a different tumor suppressor gene.

«Our data strongly suggest that KIF1Bβ, which is localized on chromosome 1p36, might be such a neuroblastoma tumor suppressor gene,» says principal investigator Susanne Schlisio at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet and Assistant Member at the Ludwig Institute for Cancer Research in Stockholm, Sweden.

Researchers have finally been able to make the charges stick against a long - suspected tumor suppressor gene.

Cancers carrying mutations in the BRCA1 and BRCA2 tumor suppressor genes are unable to undergo homologous recombination and therefore rely on a different pathway to repair their DNA and continue growing.

Now, Ludwig researchers have shown that one way to override the growth - promoting effects of PTEN deletion is, surprisingly, to inhibit a separate tumor suppressor gene.

«It was an unexpected result because these are two verified tumor suppressor genes,» said study senior author Frank Furnari, a member of Ludwig Institute for Cancer Research, San Diego.

A significant finding by the team was that either the mutant KRAS gene or another cancer gene is amplified, depending on which tumor suppressor gene is affected and to what degree its function is impaired.

«A way to stabilize haploidy in animal cells: Mammalian haploid cells present problems during mitosis that limit their viability; the removal of the p53 tumor suppressor gene increases the survival rate of these cells thereby stabilising their haploid state.»

Where there were concentrations of tumor suppressor genes alongside fewer oncogenes and fewer genes essential to survival, there was more chromosome deletion.

They generated a list of suspected oncogenes and tumor suppressor genes based on their mutation patterns — and found many more potential cancer drivers than anticipated.

An overabundance of Schwann cells in people with the genetic disorder neurofibromatosis 1 and 2 (who have mutations in the NF1 or NF2 tumor suppressor gene) has been linked to development of nerve sheath tumors.

«Among the seven novel tumor suppressor genes we found, our strongest hit was Myh9, which codes for the protein myosin IIa, a motor protein with well - known function in cell structure and cell migration,» says Schramek.

In addition, some CFSs overlap tumor suppressor genes, whose inactivation further fuels tumor progression.

p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma.

Finally, and this is very cool, the authors observed high - level organization of the regions repressed by H3K27me3 and H3K9me3, visualized here across the region of the DCC tumor suppressor gene on chromosome 18:

June 2013 — PTEN is one of the body's many tumor suppressor genes.

This accidental identification of a likely tumor suppressor gene illustrates the crosstalk ongoing at LJI and in labs worldwide, as scientists discover unexpected connections between inflammation and what were once considered unrelated diseases.

Additionally, alterations of subcellular localization through aberrant splicing or genetic mutations also provide ways to inactivate tumor suppressor genes (50).

Resolve the genomic diversity in a variety of tumors by targeting hotspots across 50 oncogenes and tumor suppressor genes relevant in a range of different solid tumors with SNV and indel mutation detection.

Tumor suppressor genes generally suppress tumor growth and control cell growth.

During his 11 years of extensive work experience in the fields of cell and cancer biology (including work on the famous tumor suppressor gene BRCA1), and biochemistry he has successfully published in peer - reviewed journals such as Molecular and Cell Biology and Cancer Research.