In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia,
tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double - edged sword.
LA JOLLA, CA — A collaborative study by researchers at the Salk Institute for Biological Studies uncovered that
the tumor suppressor p53, which made its name as «guardian of the genome,» not...
Huang, J.; Dorsey, J.; Chuikov, S.; Zhang, X.; Jenuwein, T.; Reinberg, D.; Berger, S. L. G9A and GLP methylate lysine 373 in
the tumor suppressor p53.
Several factors have been reported to induce the expression of p21waf1 / cip1 and the most important one is
the tumor suppressor p53 (16).
The cell cycle regulator p21 mediates the ability of
the tumor suppressor p53 to arrest cellular proliferation.
The tumor suppressor p53 is critical in the protection of cells against radiation - induced carcinogenesis, most likely through its ability to trigger apoptosis of radiation - damaged cells (45).
LA JOLLA, CA — A close collaboration between researchers at the Salk Institute for Biological Studies and the Institute for Advanced Study found that
the tumor suppressor p53, long thought of as...
Mice that are unable to fully activate the powerful
tumor suppressor p53 are resistant to high doses of radiation.
Loss of
tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.
In the first test using KnIT, the team sought to identify new protein kinases that phosphorylate (or turn on) the protein
tumor suppressor p53.
These effects are partly mediated by
tumor suppressor p53, which is frequently mutated in human cancers.
Loss of
the tumor suppressor p53 often contributes to therapy resistance in tumors.
A new study led by University of Kentucky researchers suggests that activating
the tumor suppressor p53 in normal cells causes them to secrete Par - 4, another potent tumor suppressor protein that induces cell death in cancer cells.
The tumor suppressor p53 does all it can to prevent oncogenes from transforming normal cells into tumor cells by killing defective cells or causing them to become inactive.
Not exact matches
Spalax naturally have a variant in the
p53 gene (a transcription factor and known
tumor suppressor), which is identical to a cancer - related mutation in humans, Band said.
One protein that keeps healthy cells from behaving this way is a
tumor suppressor named
p53.
In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the
tumor suppressor gene (
p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.
The researchers further found that miR - 486 is itself regulated by the
tumor -
suppressor gene
p53, the most frequently altered gene in human cancers, and that activity of miR - 486 is partially dependent upon functional
p53.
Numb therefore stabilizes
p53 and allows this
tumor suppressor protein to limit stem cell proliferation.
Sometimes oncogenes manage to initiate
tumor development in the presence of
p53, but, even then, the
tumor suppressor doesn't give up and focuses its efforts instead on limiting the
tumor's ability to invade and metastasize.
«These findings show that miR - 486 serves a
tumor -
suppressor function in lung cancer, and that miR - 486 action is partially dependent on
p53.»
All the fish had the human cancer mutation BRAFV600E — found in most benign moles — and had also lost the
tumor suppressor gene
p53.
Declining ATP levels activate a cellular energy sensor AMPK, which adds a phosphate group to
tumor suppressor protein
p53, extending the protein's lifetime.
In a retrospective case study involving published data on
p53, an important
tumor suppressor protein, the team showed that this new resource called the Knowledge Integration Toolkit (KnIT) is an important first step in that direction, accurately predicting the existence of proteins that modify
p53 — proteins that were subsequently found to do just that.
P53 is a
tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated
suppressor gene in cancer.
Center for Elephant Conservation, elephants have 38 additional modified copies (alleles) of a gene that encodes
p53, a well - defined
tumor suppressor, as compared to humans, who have only two.
«A way to stabilize haploidy in animal cells: Mammalian haploid cells present problems during mitosis that limit their viability; the removal of the
p53 tumor suppressor gene increases the survival rate of these cells thereby stabilising their haploid state.»
«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important
tumor suppressors like
p53.»
The scientists are planning further study of HOXA5's role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known
tumor suppressor protein
p53.
This causes genomic instability in developing immune cells and, in the absence of a working
tumor suppressor protein such as
p53, an aggressive form of lymphoma develops in mice.
Pten is the most prominent human
tumor suppressor after
p53.
Researchers from Charité — Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam - Rehbruecke have found that
p53, one of the most important
tumor suppressors, accumulates in liver after food withdrawal.
Dr. Shawn Li, PhD, and his team at Western's Schulich School of Medicine & Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a
tumor suppressor protein called
p53 - a master regulator of cell death.
Importantly, about 70 percent of LFS families have a mutation in their version of the gene TP53, which is the blueprint for protein
p53, well known by the nickname «the
tumor suppressor.»
In fact, KLF4 blocks senescence and apoptosis by repressing transcription of
P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a
tumor suppressor and an oncogene (33, 34).
Some examples from their lab include using AAV to introduce epitope tags into the endogenous alleles of the
p53 and PTEN
tumor suppressor genes in human cells (Kim et al 2008).
Within this cascade Shp2 turns on different signaling molecules, but turns off the
tumor suppressor genes p27 und
p53.
«Through further functional studies we found that myosin IIa is also required for activation of the main guardian of the genome — a
tumor suppressor protein called
p53.»
LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful
tumor suppressor called
p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc...
La Jolla, CA — The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self - destruct pivots on the
p53 tumor suppressor gene.
LA JOLLA, CA — A tightly controlled system of checks and balances ensures that a powerful
tumor suppressor called
p53 keeps a tight lid on unchecked cell growth but doesn't wreak havoc in healthy cells.
«Restoring the
tumor suppressor ability of
p53 with a drug is paramount in anti-cancer drug development,» notes Carpizo, who is an associate professor of surgery and pharmacology at Rutgers Robert Wood Johnson Medical School.
The product of the
p53 tumor suppressor gene is discovered independently by several groups: Lionel Crawford and David Lane; Albert Deleo and Lloyd Old; and Arnold Levine.
As a powerful
tumor suppressor,
p53 turns on genes that either halt cell division to allow time for repair of damaged DNA or, when all rescue attempts prove futile, to prevent cells with genetic defects from dividing, as this would fuel the development of cancer.
In back - to - back papers published online July 28 in Science, researchers from the Broad Institute, Dana - Farber Cancer Institute, Johns Hopkins Kimmel Cancer Center, the University of Pittsburgh, and the University of Texas MD Anderson Cancer Center have confirmed genetic abnormalities previously suspected in head and neck cancer, including defects in the
tumor suppressor gene known as
p53.
Although persistent loss of IGF - 1R expression ultimately induced cell stasis and death, both of these processes are regulated by the
tumor suppressor gene
p53 that is commonly mutated in human prostate cancers.
His team identified a factor that may be important for clinical trial design: progesterone was not toxic to all glioblastoma cell lines, and its toxicity may depend on whether the
tumor suppressor gene
p53 is mutated.
Efforts to combat the mutated
p53 tumor suppressor gene with targeted drugs, for example, have so far been unsuccessful.
P21 is closely related to the
tumor suppressor gene
P53: cancer suppression and enhanced regeneration are frequently found to be opposite sides of the same coin.