Sentences with phrase «tumor suppressor role»
These data confirm that LARP7 protein levels are also reduced during breast cancer progression, and thus suggest that LARP7 may play a potential tumor suppressor role in breast cancer.
https://elifesciences.org/ Not exact matches
In this special section of Science, expert contributors retrace the long and tortuous path leading to the mapping and identification of the BRCA1 gene; discuss the ways in which BRCA mutation status has been integrated into the clinical management of patients in high - risk families; and highlight the role of the BRCA proteins in preserving the structural and numerical integrity of chromosomes throughout the cell cycle, a function that may explain their tumor suppressor activity.
Correspondingly, a large number of genes with no direct role in tumor progression also are deleted as a result of their proximity to tumor suppressor genes.
In a previous study, his team worked with other collaborators to identify the potential role of extra copies of the tumor suppressor gene (p53) that increase the elephant's ability to eliminate pre-cancerous cells with DNA damage.
But it has proven difficult to collect the firm evidence needed to confirm the tumor - suppressor role.
«This is the best example that NF1 is a tumor suppressor,» says David Viskochil, a geneticist at the University of Utah, although he cautions that the case is not yet closed: There still could be other genes that play a role in NF tumor development.
«Also, because Notch is known to be a tumor suppressor, the essential role of Rumi in Notch activation suggests that Rumi could be a tumor - suppressor as well.
This study aimed to determine whether epithelial - derived MMP9 has a defensive role of tumor suppressor in CAC and the underlying molecular mechanism.
Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.
The scientists are planning further study of HOXA5's role in breast cancer, following up on this work and a study published by Sukumar's lab in 2000 that showed a connection between low levels of HOXA5 and the well - known tumor suppressor protein p53.
«Preclinical results support entinostat's role in targeting the tumor microenvironment: Entinostat inhibits function of myeloid derived suppressor cells resulting in enhanced antitumor effect in murine models of lung and renal cell carcinoma.»
The tumor suppressor gene PTEN is known to play a major role in prostate cancer; its partial loss occurs in up to 70 percent of primary prostate tumors.
Applying their technique to head and neck cancers, they've discovered seven new tumor - suppressor genes whose role in cancer was previously unknown.
Finally, Dr. Goldenring's laboratory is also investigating the role of Rab25 as a tumor suppressor in the colon using the Rab25 - / -; Smad3 + / - mouse model, which develops spontaneous invasive distal colon cancers.
P53: The protein p53 plays the role of tumor suppressor, but creating a general increase in p53 levels will, in addition to reducing cancer incidence, also accelerate aging by reducing tissue maintenance through the creation of new cells.
She chose the dynamics and function of the tumor suppressor protein p53, which plays a key role in cancer and is widely studied.
We have appreciated for some time the causes of this uncontrolled proliferation, in particular the roles of proto - oncogenes, tumor suppressors, and their protein products.
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
One may compare the roles of proto - oncogenes and tumor suppressors to the accelerator and brake pedal of a vehicle, respectively.
And in view of PTEN's critical role as a tumor suppressor, it's also important that the process we uncovered is a controlled one, not random as was previously believed.»
Together, our data highlight mechanical roles for proto - oncogene and tumor suppressor pathways in cell - cell interactions.
Tumor suppressors and proto - oncogenes play crucial roles in tissue proliferation.
Combining genetics, live - imaging, laser ablation and computer simulations, we aim to analyze whether distinct or similar mechanisms can account for the common role of tumor suppressors and proto - oncogenes in cell - cell contact regulation.
Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
9) Thu KL, Radulovich N, Becker - Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt / β - catenin signaling.
The role of histone codes and DNA methylation in silencing tumor suppressor genes, Cancer Cell 3:89 - 95, 2003.
In essence, Knudson, far ahead of his time (and ahead of his own hard data) hypothesized that some genes» normal role in life is to behave as anticancer or tumor - suppressor genes that keep cell division under healthy control.
A role of HUWE1 has been very controversial in the context of cancer biology — some studies report HUWE1 as a tumor suppressor, while other studies show HUWE1 as having the potential to cause cancer.