Sentences with phrase «tumor tissue»

This may involve taking samples of tumor tissue, it may mean removing the whole tumor, or it may be an attempt to remove as much of the tumor as possible.

The researchers used tumor tissue samples from melanoma patients to search for variations in their internal messaging.

In particular, the molecular mechanisms by which fat cells communicate with tumor tissue remain poorly understood.

Of the 104 screened patients, 102 enrolled with 91 (89 percent) having adequate tumor tissue to complete sequencing.

There, it attacks the surrounding tumor tissue and contrary to conventional PDT, it does not require any oxygen for this purpose.

Over the past several years he has recruited tumor tissues and blood samples from thousands of dogs presenting with a variety of cancers, as well as their family members.

• Availability of tumor tissue is mandatory for study eligibility.

These are listed above in increasing order of value to researchers with tumor tissue being the highest value.

myPlan Lung Cancer testing should be performed on resected tumor tissue from patients diagnosed with pathological stage I or II lung adenocarcinoma following definitive surgical resection.

The eventual goal of this research is to develop the instrument to a degree that it is FDA approved and can speed up the process of pathology interpretation of brain tumor tissue.

Laser Light Test Reveals Spreading Cancer Cancer imaging and breast cancer experts used advanced microscopes equipped with tissue - penetrating laser light to develop a promising new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread.

She holds the Pamela Cole Chair in Companion Animal Medicine, is an Associate Director of the Mari Lowe Center for Comparative Oncology and is the Director of the PennVet Tumor Tissue Bank.

An additional set of 18 prostate cancer tissue samples was analyzed by qPCR and five lncRNAs were found to be significantly higher in prostate tumor tissues compared with matched normal tissues.

Philadelphia, PA About Blog The Children's Brain Tumor Tissue Consortium is committed to discovering new cures and better therapies for children with pediatric brain tumors.

This goal became a reality in the fall of 2006 when the Berner - Garde Foundation (BGF) and Michigan State University (MSU), with support from the Bernese Mountain Dog Club of America (BMDCA) signed a contract to establish a DNA and Tumor Tissue Repository to be housed at Michigan State University.

For unclear reasons, the copper metabolite is 10 times more abundant in tumor tissue compared with other tissues, the group found.

Patients with recurrent glioblastoma multiforme (GBM) treated with an experimental vaccine made from the patient's own resected tumor tissue showed an improved survival compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine that was recently published in the journal Neuro - Oncology and accompanied by an editorial highlighting the importance of the trial.

When researchers at Johns Hopkins University in Baltimore, Maryland, examined tumor tissue from the original man with colon cancer who responded to a PD - 1 inhibitor, they found a clue: His tumor had mutations in «mismatch repair» genes, so - called because their encoded proteins fix errors in DNA bases when cells replicate their DNA.

Sorenmo's Canine Mammary Tumor program at the University of Pennsylvania's Ryan Veterinary Hospital, in partnership with Princeton University, has now enrolled about 145 «underdogs,» offering them needed surgeries, collecting tumor tissue for the ongoing genomic studies, and placing them in new homes that will help with follow - up research.

Patient - derived xenographs involve the implantation of tumor tissue into an immunodeficient mouse which becomes an avatar to help identify which drug or drug combinations are most likely to be effective for an individual cancer patient.

For example, knowing that IL - 37 helps to create overall immune system sensitivity could allow researchers to manipulate IL - 37 levels to sensitize the immune system to recognize and target tumor tissue, or desensitize the immune system in auto - immune conditions like rheumatoid arthritis in which the immune system acts over-aggressively toward healthy tissue.

Examining expression levels of H2AX in breast cancer tumor data from The Cancer Genome Atlas, a large National Institutes of Health database containing genetic information about tumor tissue from more than 11,000 patients, the Roswell Park team found that breast cancer patients whose tumors had high levels of H2AX had a significantly worse prognosis than those with low levels.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

«How can we overcome the limitations of tumor tissue biopsy and plasma samples for detecting genetic alterations, and obtain comprehensive tumor EGFR profiling in real - time?»

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Dr. Breen's lab is looking for DNA (blood) or fresh tumor tissue samples.

After you fill out the online survey, we will ask you to fill out an online consent form that requests your permission to obtain copies of your medical records and some of your stored tumor tissue.

The diagnosis of the TVT was further supported by the identification and analysis of long interspersed nuclear elements (LINE) from paraffin - embedded tumor tissue.

Furthermore, there was no discernable brain tumor tissue detected using magnetic resonance (MRI) or fluorodeoxyglucose - positron emission tomography (FDG - PET) imaging scans.14

The spice targets only cancerous cells causing them to self - destruct by destroying the mitochondria that power the rapidly growing tumor tissue.

IHC - P mouse tumor tissue (from lung) with human cell line injected, some muscle tissue attached as well sees high background for human cellswith priamry Ab as well as isotype ctrl, but also for muscle (does not contain any EGF) Ab: 1 ug /...

Additionally, organizations such as Freiburg - based Oncotest, a company founded and directed by Fiebig, and the Jackson Laboratory in Bar Harbor, Maine, provide access to a wide range of PDX mice made from donated tumor tissue.

To conduct their study, Kaur, Baiocchi and their colleagues used tumor tissue from patients, cell lines and an animal model.

Plasma samples of patients with NSCLC is a less invasive method and has been used as surrogate tumor tissues for detecting genetic alterations.

«The ability to test our ideas in tumor tissues removed from patients underscores the unique and multi-disciplinary nature of our Prostate Cancer Program, one of only eight Prostate Cancer Programs of Excellence in National Cancer Institute Designated Centers,» said Dr. Knudsen.

In this latest study, researchers were able to demonstrate the ability of the nanosensor to illuminate tumor tissue in multiple mouse models.

The researchers also showed that profiling a patient's tumor tissue according to these functional shifts served as an effective method to predict their cancer subtype and their survival.

The team reports that Sema3D was abundant in the main tumor tissue of only three of 13 (23 percent) patients who died after minimal cancer spread.

A team of researchers in Baltimore tested tumor tissue and healthy tissue from 815 patients who had various cancers.

«Surgery is the most important treatment for ovarian cancer, and surgeons mainly have to rely on their naked eyes to identify tumor tissue, which is not optimal.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF - 1 receptor.

«In our practice, we recommend that all patients with baseline EGFR T790M identified in their lung tumor tissue be referred to clinical genetics to discuss EGFR T790M germline testing.

«Prior research in the field has primarily focused on using knowledge from tumor tissue sequencing to identify specific changes to look for in circulating tumor DNA.

Researchers believe it is the largest epigenetic study yet for any single cancer type and, importantly, the first to use a large cohort of primary patient tumor tissues instead of cell lines grown in the laboratory.

When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells in pancreatic tumor tissue, as well as a slowing of tumor growth.