Sentences with phrase «tumor tissue sequencing»

«Prior research in the field has primarily focused on using knowledge from tumor tissue sequencing to identify specific changes to look for in circulating tumor DNA.

Not exact matches

A tissue slice, a tumor biopsy, or a sample of a bacterial culture yields a sequence representing the average of all of the cells within it, even though researchers know there can be tremendous variation between those cells.

Of the 104 screened patients, 102 enrolled with 91 (89 percent) having adequate tumor tissue to complete sequencing.

To illuminate the process, the Yale team sequenced normal, primary, and metastatic tumor tissue from multiple individuals, including subjects with a range of cancer types.

Investigators compared DNA from the liquid blood biopsies to DNA tissue samples from the tumor, using mate - pair sequencing — an inexpensive whole exome sequencing that can reveal genetic changes that contribute to tumor growth.

NYGC computational biologists and members of the Simon Laboratory at The Rockefeller University discussed the possibility of using a series of computer algorithms to search for sequence differences between the tumor samples and samples of healthy liver tissue.

«Our findings show that high - intensity circulating tumor DNA sequencing is possible and may provide invaluable information for clinical decision - making, potentially without any need for tumor tissue samples,» said lead study author Pedram Razavi, MD, PhD, a medical oncologist and instructor in medicine at Memorial Sloan Kettering Cancer Center (MSK) in New York, NY.

Another collaboration was unfolding among the cancer geneticists, sequencing experts, clinical researchers, and surgical oncologists at Johns Hopkins, MD Anderson, and Baylor College of Medicine to study 32 pairs of head and neck tumor and normal tissue samples by whole - exome sequencing and validate the findings in an additional 88 samples.

Just as one can't truly identify somatic mutations in a tumor tissue without a matched normal, it's nearly impossible to distinguish de novo mutations in a patient without sequencing both of his or her parents.

Grandis and Garraway decided to study a University of Pittsburgh collection of 74 pairs of tumor and normal tissue samples using the Broad's capacity to perform whole - exome sequencing.

Past genomic studies of cancer compared sequencing data from patients» healthy tissue and the same patients» tumors.

Fluorescence in situ hybridization (FISH) was used to screen for the presence of XMRV genomic sequences in formalin - fixed, paraffin - embedded (FFPE) tissue sections from VP62 (2012) and 19 newly collected tumors (a subset of the 39 individuals in the prospective study).

Mammary tumor virus sequences have not been detected in normal breast tissue or other tumors.