Sentences with phrase «tumor vasculature»
"Tumor vasculature" refers to the network of blood vessels that supply nutrients and oxygen to a tumor or cancerous growth. Full definition
Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.
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Rehemtulla adds that if other FDA - approved chemotherapeutic agents reach their targets as successfully as Photofrin did, «then we will have developed a way to make cancer drugs more «tumor - specific,» because they will only get into tumor vasculature and not normal vasculature.
As expected, trastuzumab distribution was heterogeneous and localized in the vicinity of tumor vasculature.
Results published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer (IASLC), show that low preoperative levels of squamous cell carcinoma antigen in the serum or either absence of tumor invasion into the pleura (the space between the lungs and chest wall) or tumor vasculature are independent prognostic factors for patients with any stage of p - SCC.
With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.
The target molecule of the immunization strategy is the extra domain - A (ED - A) of fibronectin, a protein domain which is highly selective for the tumor vasculature in the adult.
«The SFRP2 - moleculary targeted contrast agent showed specific visualization of the tumor vasculature,» said Dr. Klauber - DeMore.
The occurrence of reoxygenation following hypoxic exposures of various degrees is inherent in the dynamic nature of the tumor vasculature [43, 44].
We showed that the EphA2 receptor is upregulated in the tumor vasculature together with the ephrin - A1 ligand, which suggested a role in tumor angiogenesis that is now well established.
He and his collaborators subsequently hypothesized that normalizing the microenvironment may improve treatment outcome and subsequently have demonstrated that judicious use of antiangiogenic agents — originally designed to starve tumors — could transiently «normalize» tumor vasculature, alleviate hypoxia, increase delivery of drugs and anti-tumor immune cells, and improve the outcome of various therapies, including immunotherapy.
The NAVBO Meritorious Awards Committee and Council is pleased to announce the selection of Rakesh K. Jain, Ph.D., as the 2018 recipient of the Earl P. Benditt Award, in recognition of his numerous contributions to our understanding of the unique characteristics of tumor vasculature.