In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had
tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had
tumor volumes ranging
from 150 to 400 cubic millimeters at eight weeks.
«Both total metabolic
tumor volume (TMTV), computed on baseline PET, and end - of - induction PET (EOI PET) are imaging biomarkers showing promise for early risk stratification in patients with high
tumor - burden follicular lymphoma,» reported lead author Anne Ségolène Cottereau, MD,
from Cochin Hospital, René Descartes University, Paris, France, and colleagues.