It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous
tumor xenograft model via suppression of autophagy [Submitted].
Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary
tumor xenograft models.
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived
tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.
Not exact matches
Additional experiments also showed that TiY can suppress the
tumor growth in mice
xenograft model.
Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated
tumor development in
xenograft models and in Sqle transgenic mice.
EZH2 inhibition delayed
tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder
tumors in both patient - derived and cell line
xenograft models.
We created a mouse
xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant
tumors were treated with PAL three times a week for 6 weeks.
We then usually move onto
xenograft models and then also, if available, try to test some of these compounds in genetically engineered mouse
models that have particular mutations driving
tumor formation.
In a 1988 paper summarizing his findings, Fiebig concluded that
xenograft mice were wonderful
models for broadly testing new drugs against human
tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using
xenograft mice as personal avatars for cancer patients was discarded.
The researchers used an in vivo
model of PARP inhibitor resistance in patient - derived
tumor xenografts (PDXs).
«There is some talk of going into 3 - D cell
models rather than
xenografts, because it is so difficult and challenging to grow [the transplanted
tumors],» says Manish Kohli, the Mayo Clinic oncologist leading the PROMOTE study.
NCI's efforts to develop new laboratory
models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived
tumor xenografts.
Due to the high efficiency of establishing organoid
models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of
tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and
xenograft - based drug studies (7,19).
Most
xenograft models for brain
tumors using
tumor cell lines require at least 10,000 cells.
Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer
tumors, and prostate cancer samples derived through mouse
xenograft models.
In a
xenograft KMT2D - mutated T - lymphoma
model, dual treatment with chidamide and decitabine significantly retarded
tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.
(G) Immunostaining of p - ERK in
tumor samples of
xenografted murine
models bearing KMT2D V5486 mutants treated with CHID and / or DECI.
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human
tumor cell lines and
xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.
Acquired
tumor cell resistance to sunitinib causes resistance in a HT - 29 human colon cancer
xenograft mouse
model without affecting sunitinib biodistribution or the
tumor microvasculature
The approach is to use clinically relevant
tumor models such as patient - derived
xenografts (PDXs), as well as humanized and immunocompetent transgenic
tumor - bearing mice to design rational combinations of novel and emerging cancer therapies, including
tumor - targeting and immune - stimulating therapies, to ultimately improve treatment outcomes for cancer patients.
We next tested the ability of antibody - expressing NSCs to deliver anti-HER2 antibodies to
tumor foci in vivo using a
xenograft nude - beige mouse
model.
These platforms include genetically engineered mouse (GEM)
models, fallopian tube - derived cell lines, and patient - derived
tumor xenografts.
ONC201 combined with cytarabine in a Burkitt's lymphoma
xenograft model induced
tumor growth inhibition that was superior to either agent alone.
ONC201 combined with bortezomib in a Burkitt's lymphoma
xenograft model reduced
tumor cell density and improved CHOP induction compared to either agent alone.
Over 170 carefully curated, well - characterized patient - derived
xenograft tumor models are available for use in your facility, or use Horizon's comprehensive preclinical in vivo efficacy service.