Sentences with phrase «tumor xenografts»

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf G, English J, Kirschmeier PT, Velculescu VE, Paweletz CP, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.: Establishment of patient - derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics.

When given alone, it significantly slows the growth of tumor xenografts of human recurrent small - cell lung cancer in mice.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

To improve our understanding and to build better and more translatable in vivo mouse tumor models, we are developing humanized mouse models consisting of the transplant of patient - derived tumor xenografts into immunodeficient mice reconstituted with human immune cells (isolated from the matching patient from the draining LNs or with allogenic PBMCs or LN cells).

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

Using 80 of the successful tumor xenografts — from the Greek «xenos» meaning «foreign» — he compared how the mouse's tumor responded to a drug or drug combination with the treatment response of the corresponding human patient.

Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].

Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft models.

We have recently reported that the GHRH antagonist, MIA - 602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.

The researchers used an in vivo model of PARP inhibitor resistance in patient - derived tumor xenografts (PDXs).

«[The technique] requires further evaluation and validation before it's ready for everyone to just go and have their tumor xenografted.»

NCI's efforts to develop new laboratory models of human cancer includes vastly increasing the number of human cancer cell lines (grown as two - dimensional and three - dimensional cultures) and patient - derived tumor xenografts.

Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN / 12 -1 in SKBR - 3 cells, and tumor xenografts.