Sentences with phrase «tumor xenografts in»

Moreover, following transformation with H - Ras, these cells initiated tumor xenografts in immunocompromised mice with higher efficiency than their epithelial counterparts [5].

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

Not exact matches

Finally, they were also able to reduce tumor growth in their first in vivo xenograft analysis.

Additional experiments also showed that TiY can suppress the tumor growth in mice xenograft model.

To overcome these problems, Min and his team developed a new modality to visualize glucose uptake activity inside single cells based on stimulated Raman scattering (SRS) imaging, and demonstrated its use in live cancer cells, tumor xenograft tissues, primary neurons and mouse brain tissues.

Terbinafine, a U.S. Food and Drug Administration — approved antifungal drug targeting SQLE, markedly inhibited SQLE - induced NAFLD - HCC cell growth in NAFLD - HCC and HCC cells and attenuated tumor development in xenograft models and in Sqle transgenic mice.

EZH2 inhibition delayed tumor onset in KDM6A - null cells and caused regression of KDM6A - null bladder tumors in both patient - derived and cell line xenograft models.

We created a mouse xenograft model in which SiHa cervical cancer cells were injected into mice subcutaneously, and the resultant tumors were treated with PAL three times a week for 6 weeks.

We then usually move onto xenograft models and then also, if available, try to test some of these compounds in genetically engineered mouse models that have particular mutations driving tumor formation.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

The researchers used an in vivo model of PARP inhibitor resistance in patient - derived tumor xenografts (PDXs).

Personal drug regimens based on xenograft mice harboring a single patient's tumor still need to prove their true utility in medicine.

These days, mice grafted with human tumors, known as patient - derived xenograft (PDX) mice, are common in cancer research laboratories.

Since starting her new role as an investigator in the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelin the In Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelIn Vivo Pharmacology group at Novartis Oncology, Bhang has been working on using the ClonTracer library to monitor clonal dynamics following drug treatment in cell line and primary tumor xenograft modelin cell line and primary tumor xenograft models.

Zebrafish larva implanted with cancer patient's tumor (red) RITA FIOR / CHAMPALIMAUD CENTRE FOR THE UNKNOWNSee R. Fior et al., «Single - cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts,» PNAS, doi: 10.1073 / pnas.1618389114, 2017

Finally, I have a category of «other cancers» with exomes published in 2011; these include pancreastic cysts and cell lines, gastric cancer tumors, and prostate cancer samples derived through mouse xenograft models.

Comparative genomic hybridization showed a normal pattern in the first case and a gain of chromosomal 12 in the xenografted tumor.

In a xenograft KMT2D - mutated T - lymphoma model, dual treatment with chidamide and decitabine significantly retarded tumor growth and induced cell apoptosis through modulation of the KMT2D / H3K4me axis.

(G) Immunostaining of p - ERK in tumor samples of xenografted murine models bearing KMT2D V5486 mutants treated with CHID and / or DECI.

In - vivo treatments of xenografted tumors showed significant tumor growth inhibition induced either by rituximab or gemcitabine alone and an impressive efficacy of combined treatment.

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD4In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD4in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

It was indeed found DAXX promotes the in vivo tumorigenicity of two human PCa cell lines in a subcutaneous tumor xenograft model via suppression of autophagy [Submitted].

Accordingly, p - ERK upregulation was observed not only in tumor samples of PTCL - NOS patients with KMT2D mutations, but also in those of xenografted T - lymphoma mice bearing KMT2D V5486M mutants, the latter being inhibited by combined treatment with chidamide and decitabine (Figure 5F, G).

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.

We also found that the EphB4 receptor expressed on the surface of breast cancer cells can promote tumor xenograft growth by enhancing blood vessel formation through interactions with its preferred ligand, ephrin - B2, present in tumor endothelial cells.

We have recently reported that the GHRH antagonist, MIA - 602, suppresses the expression of inflammatory cytokines in human TNBC tumors xenografted into nude mice.

Acquired tumor cell resistance to sunitinib causes resistance in a HT - 29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

To purify tumor cells, PC3 xenograft tumors were aseptically dissected out from animals and minced into ∼ 1 - mm3 pieces in RPMI - 7 % FBS.

Intraperitoneal injection of the HIF - 1α inhibitor, YC1, following tumor initiation reduces the hypoxic CSC effect in MCF7 xenografts and results in no correlation between xenograft size and MFC (Fig. 5C).

On the contrary, recent evidence indicates that XMRV is a contaminant originating from the recombination of two mouse endogenous retroviruses during passaging of a prostate tumor xenograft (CWR22) in mice, generating laboratory - derived cell lines that are XMRV - infected.

A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease, integrating DNA sequencing of patient tumors with the generation of patient - derived organoids and xenografts.

We also demonstrate that immunoglobulin - secreting NSCs exhibit preferential tropism to tumor cells in vivo, and can deliver antibodies to human breast cancer xenografts in mice.

We next tested the ability of antibody - expressing NSCs to deliver anti-HER2 antibodies to tumor foci in vivo using a xenograft nude - beige mouse model.

Importantly, an inverse correlation was observed for ER - α — negative lines with a decrease in the proportion of MFC within the xenograft as tumor size increases (Fig. 5Bii).

ONC201 combined with cytarabine in a Burkitt's lymphoma xenograft model induced tumor growth inhibition that was superior to either agent alone.

A, HIF - 1α and Glut1 expression in ER - α — positive (i) and negative (ii) xenografts compared with tumor size (mm3).

ONC201 combined with bortezomib in a Burkitt's lymphoma xenograft model reduced tumor cell density and improved CHOP induction compared to either agent alone.

Autophagy inhibition synergistically enhances anticancer efficacy of RAMBA, VN / 12 -1 in SKBR - 3 cells, and tumor xenografts.

This included evaluation of tumor burden in mice orthotopically xenografted, as well as analysis of the overall rate of survival.

Over 170 carefully curated, well - characterized patient - derived xenograft tumor models are available for use in your facility, or use Horizon's comprehensive preclinical in vivo efficacy service.

HCMV and COX - 2 expression correlated in primary tumors, cell lines, and medulloblastoma xenografts.

Sulforaphane, a putative anticarcinogen in broccoli, was provided orally to mice bearing androgen - insensitive human PC - 3 xenografts, and resulted in tumor volumes of 207 ± 35 and 90 ± 22 mm3 for the control and sulforaphane groups, respectively (22).