Sentences with word «tumorigenesis»

Modulation of tumorigenesis by the pro-inflammatory microRNA miR - 301a in mouse models of lung cancer and colorectal cancer.

Dr. Harris is a renowned expert on the role of COX - 2 in chronic inflammation and in promoting tumorigenesis and angiogenesis, and has authored numerous papers in peer - reviewed journals and book chapters on the use of NSAIDS and selective COX - 2 inhibitors in the chemoprevention of various cancer types.

Understanding how interactions between these tissues are regulated will indicate pathways that may also function in those interactions that occur during tumorigenesis in the adult.

Stem cell researcher Paul Knoepfler of the University of California, Davis, who was not involved in the work, noted on his blog that the studies did not delve into the frequencies of mutations or the potential for tumorigenesis in the chemically reprogrammed cells.

Pooled in vivo screen and gene expression profiling identified functional variants and demonstrated that expression of rare variants induced tumorigenesis.

Embryonic stem cells (ESCs) represent a source for the large numbers of modified EPCs required to therapeutically inhibit tumorigenesis [3], although patient - specific induced pluripotent stem cells (iPSCs) represent a more attractive option.

IBD is known to promote colon tumorigenesis and gave rise to the term «colitis - associated cancer.»

Evidence exists that chronically elevated blood glucose, insulin and IGF1 levels facilitate tumorigenesis and worsen the outcome in cancer patients.

In this issue of Developmental Cell, Levine et al. (2017) provide strong evidence that centrosome amplification is sufficient to initiate tumorigenesis in a mouse model.

Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model.

Dallosso AR, Øster, B, Greenhough A, Thorsen K, Curry TJ, Owen C, Hancock AL, Szemes M, Paraskeva C, Frank M, Andersen CL, Malik K. Long - range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Increased spontaneous tumorigenesis; accelerated development of HBV - induced premalignant lesions; mammary gland and splenic germinal center hyperplasia.

Using a comprehensive integration of genomic and molecular approaches we will determine the biochemical context in which AR signaling drives breast cancer tumorigenesis.

Ellagic acid inhibited lung tumorigenesis induced by NNK in A / J mice.

The research team, comprising Assistant Professor Sudhakar Jha, Dr Vanitha K. Subbaiah and Mr Zhang Yanzhou, found that HPV E6 oncogene interacts with EDD1 to destabilise the TIP60 protein, thereby resulting in an increased tumorigenesis.

«As bioengineers, we can now design 3D culture systems where environmental parameters such as composition, porosity, and stiffness can be precisely tuned to study the importance of these cues on tumorigenesis,» says coauthor Sandeep Koshy, a Harvard graduate student in the Harvard - MIT Program in Health Sciences and Technology, who works in Mooney's lab at Harvard SEAS and at the Wyss Institute for Biologically Inspired Engineering.

The mammary epithelial cells eventually stop proliferation at late stages of pregnancy, impairment of which potentially results in breast tumorigenesis.

«This novel technique,» they said, «should help distinguish and monitor cancer stages and progression, aid in elucidation of basic mechanisms underlying tumorigenesis, and facilitate analyses of processes related to early detection of cancer, screening and / or cancer risk assessment.»

Tiny changes in our genomes can enhance oncogene expression and contribute to tumorigenesis [Also see Report by Mansour et al..]

Interestingly, BRCA1 is not a haploid - insufficient tumor suppressor gene; therefore monoallelic deletion may not affect its function or affect tumorigenesis of those breast cancers bearing deletions.

This discovery will therefore help researchers dissect the cell - specific events mediating tumorigenesis in the particular case of Merkel cell carcinoma.

TGFβ inhibits tumor initiation and progression by inducing cell cycle arrest and apoptosis; however epithelial tumorigenesis may escape this common antitumor mechanism by inducing aberrations in TGFβ signaling resulting in enhanced development and progression of human carcinomas.

Putoczki T, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PL, Nguyen P, Preaudet A, Farid R, Edwards K, Boglev Y, Heath JK, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Sieber O, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS and Ernst M. Interleukin - 11 is the dominant IL - 6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.

He studied normal development and tumorigenesis using genetically modified mice and published his findings in very high impact journals.

These results reveal that aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53 - deficient cells.

This new concept of ovarian tumorigenesis has been a paradigm shift in the field and the Drapkin lab has been at the forefront in developing novel experimental platforms that address the role of the FT epithelium and its susceptibility to neoplastic transformation.

(2015) Fluorophore - NanoLuc BRET reporters enable sensitive in vivo optical imaging and flow cytometry for monitoring tumorigenesis.

Expression is lost upon tumorigenesis (T).

Recent evidence suggests that overstimulation of zonulin in susceptible individuals could dysregulate intercellular communication promoting tumorigenesis at specific organ sites -LSB--RSB-.

HPV E6 binds with EDD1 to ubiquitinate TIP60, leading to the degradation of TIP60, eventually resulting in tumor tumorigenesis.

Subsequently, the role of p21 in mediating tumor suppression has been examined in a number of murine models for tissue - specific tumorigenesis.

His research program is interested in understanding how cellular metabolism regulates tumorigenesis.

Many of these kinases are involved in growth - related pathways, tumorigenesis pathways, and cell cycle control, such as Aurora kinase B (Borisa and Bhatt, 2017).

The central focus of my future work is to elucidate the mechanisms by which tumorigenesis results in the conversion of TGFβ from a suppressor of tumor formation to a promoter of tumor growth, invasion, and metastasis.

Smoothened (Smo) is a 7TMR that mediates effects of Hedgehog on developmental processes and whose dysregulation may cause tumorigenesis.

In the absence of telomerase, telomere shortening limits cellular life span and prevents tumorigenesis.

Interestingly, Yu and colleagues recently showed that knockdown of KLF4 decreased the proportion of cancer stem cells, whereas overexpression of this gene led to an increase in the cancer stem cell population, suggesting that KLF4 plays a strong oncogenic role in mammary tumorigenesis likely by maintaining stem cell - like futures of breast cancer cells (29).

The prevention of intestinal tumorigenesis by Dnmt1 deficiency and by DAC has been demonstrated in the Min mice, which carry a mutated Apc gene (38, 39).

The pancreas seems to require two oncogenic events to initiate and promote tumorigenesis with tumor suppressors acting later to increase progression to malignant disease.

Their findings, «Initiation of Inflammatory Tumorigenesis by CTLA4 Insufficiency Due to Type 2 Cytokines,» were published online on January 26 by the Journal of Experimental Medicine.