Sentences with phrase «tumorigenesis at»
Adjuvants Role in Pathogenesis of FISS In 1993, an epidemiologic study involving 345 cats with fibrosarcoma provided evidence that vaccination with feline leukemia virus (FeLV) and rabies virus vaccines could lead to tumorigenesis at the injection site, particularly when vaccination was repeatedly administered at the same site.6
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As a doctoral student in the lab of Drs. Margaret Wheelock and Keith Johnson at the University of Toledo, Dr. Islam focused on identifying a link between cadherins (a family of cell adhesion proteins) and tumorigenesis (start of cancer cell formation).
«As bioengineers, we can now design 3D culture systems where environmental parameters such as composition, porosity, and stiffness can be precisely tuned to study the importance of these cues on tumorigenesis,» says coauthor Sandeep Koshy, a Harvard graduate student in the Harvard - MIT Program in Health Sciences and Technology, who works in Mooney's lab at Harvard SEAS and at the Wyss Institute for Biologically Inspired Engineering.
«The vaccination approach we have employed is not prophylactic but therapeutic, meaning that immunity was induced after the onset of tumorigenesis — a scenario that resembles the clinical conditions much more closely than prophylactic immunization studies, says Anna - Karin Olsson, researcher at the Department of Medical Biochemistry and Microbiology at Uppsala University,» who has led the study.
The tumorigenesis mechanisms of colorectal cancer have been widely studied at a molecular level.
For γ - radiation tumorigenesis, 1 - month - old mice were irradiated weekly for 4 weeks with a 1.75 - Gy dose from a 137Cs source (MARK 1 - 30 Irradiator; Shepherd & Associates) at a rate of 1.14 Gy / min.
GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune cell - mediated functions, proliferation, invasion and survival at the secondary site.
After a two - year stint as a postdoctoral research fellow in Pharmacology in the laboratory of Dawn Quelle at the University of Iowa, where I studied the molecular mechanisms of tumorigenesis, I made the switch to industry.
We use this in vitro model of spontaneous tumorigenesis to generate a library of cell lines with 25 different de novo JAK1 - activating mutations, 6 of which are targeting two residues, Phe958 and Pro960, located in the hinge region at the periphery of the ATP - binding pocket.
About half of all cases harbored at least one mutation in an SMG, and the frequencies of SMG mutations suggested that they were early, driver events in tumorigenesis.