Sentences with phrase «tumorigenesis pathways»

Many of these kinases are involved in growth - related pathways, tumorigenesis pathways, and cell cycle control, such as Aurora kinase B (Borisa and Bhatt, 2017).

Not exact matches

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

Smyd3 function is required for the activation of oncogenic pathways, cell proliferation and epithelial to mesenchymal transition during tumorigenesis.

Dallosso AR, Øster, B, Greenhough A, Thorsen K, Curry TJ, Owen C, Hancock AL, Szemes M, Paraskeva C, Frank M, Andersen CL, Malik K. Long - range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

With the help of cancer biologists, these data will be leveraged to better understand the genes, proteins, and pathways underlying tumorigenesis.