Sentences with phrase «tumorigenic models»
Not exact matches
Development of a bioengineered model to quantitatively measure the tumorigenic properties of cancer - associated fibroblasts in human prostate cancer.
http://additivebiomanufacturing.org/
In our laboratory, we have previously described an in vitro model of spontaneous transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).
Design and Methods Taking advantage of a model of spontaneous cellular transformation, we sequenced JAK1 in selected tumorigenic BaF3 clones and identified 25 de novo JAK1 activating mutations, including 5 mutations already described in human leukemias.
The transformation of BaF3 phe116 into autonomous tumorigenic clones is a two - step model of tumorigenesis.