The pathologist of the Department of Pathology at the University Hospital of Bellvitge August Vidal explained that «
this tumorigenic transformation depends on Dicer protein that could serve as a marker for the presence of tumor cells, or as a therapeutic target.»
Not exact matches
In our laboratory, we have previously described an in vitro model of spontaneous
transformation of the IL -3-dependent hematopoietic BaF3 cell line towards growth factor - independent
tumorigenic clones with constitutive STAT5 activation.14 This model was developed from the study of BaF3 cells transfected with an IL - 9Rα mutant lacking the STAT - recruiting site (BaF3 phe116).
Design and Methods Taking advantage of a model of spontaneous cellular
transformation, we sequenced JAK1 in selected
tumorigenic BaF3 clones and identified 25 de novo JAK1 activating mutations, including 5 mutations already described in human leukemias.
The
transformation of BaF3 phe116 into autonomous
tumorigenic clones is a two - step model of tumorigenesis.