Recent active research in miRNA identified a series of this type of molecules that are involved in tumor progression in various
tumors as oncogenes and tumor suppressors (8, 9).
Not exact matches
However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key
tumor suppressor genes such
as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS
oncogene that is known to be mutated in smoking - related lung cancers.
«Once this novel
tumor - homing agent binds to the EphA2 receptor, the
oncogene functions
as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.
«Our study identified miR - 182
as a glioblastoma
tumor suppressor that reduces the expression of several
oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.
But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described
as an
oncogene that promotes cancer because it was believed to inactivate the Rb
tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.
«It wasn't known whether miR - 486 functioned
as an
oncogene or a
tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.
«This function for BAI1 may have implications for cancer biology, since MDM2 can function
as an
oncogene by degrading important
tumor suppressors like p53.»
That will include validating some of the new predicted
tumor suppressors and
oncogenes as well
as «making some deletions and amplifications and seeing if they have the properties we think they do,» said Elledge.
The authors uncover the cellular and molecular mechanisms,
as well
as the gene network regulated by Sox9 during the early steps of skin
tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of
oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.
In humans, cancer develops when genes that suppress cancer, known
as tumor suppressors, are lost and when mutations or genes that promote cancer, known
as oncogenes, are gained or activated.
But the idea fell out of fashion
as researchers began to discover that mutations in specific
oncogenes and
tumor - suppressor genes could set cancer in motion.
In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both
as a
tumor suppressor and an
oncogene (33, 34).
In breast cancer, miR - 21, 155, 27, 96, 182, and 128 were identified
as oncogenes, whereas miR - 125, 205, 27, 17, 206, and 145 were found to be
tumor suppressor genes, and their corresponding target genes were also defined (10 — 12).
Consequently, these
tumor samples were classified
as oncogene - positive.
In response to cellular stress such
as DNA damage,
oncogene activation, transcriptional inhibition, and hypoxia,
tumor suppressor p53 is activated and expressed, and acts
as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].
But a puzzle remains: if a drug wipes away methylation indiscriminately, that might turn on an
oncogene just
as much
as it might restore a
tumor suppressor gene.
Using a model where K - ras acts
as an
oncogene and initiates
tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14
tumors / mouse for those with Notch1 function still remaining.
«The genotoxicity of mainstream smoke carcinogens manifests
as mutations occurring in key cancer - related genes, i.e., proto -
oncogenes or
tumor suppressor genes that control crucial cellular functions, e.g., growth and survival, in lung
tumors of active smokers.»