The prognosis for metastatic cancer (also called stage IV cancer) is generally poor, so a technique that could detect these circulating tumor cells before they have a chance to form new colonies of
tumors at distant sites could greatly increase a patient's survival odds.
This allows cancer cells to break off from tumors, spread throughout the body (in blood or other fluid) and form new
tumors at distant sites — a process called metastasis.
Not exact matches
When the dendritic cells are activated, they train T cells — their allies in the adaptive arm of the immune system — to attack cancer cells anywhere in the body, whether
at the
site of the original
tumor or
distant metastases.
Studies in cancer patients indicate reduced rates of relapse when patients are pretreated with epigenetic drugs due to its far - reaching capabilities; killing progenitor cells
at the
site of the
tumor, in circulation, or
at a
distant site.
Eventually some
tumor cells may break off and establish new growths (metastases)
at distant sites.
«The recent discovery of
tumor - promoting milieus, referred to as metastatic niches, that are established
at distant sites prior to or upon the arrival of disseminated
tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what
tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»
Importantly, it's secretion from normal cells can be induced by activating p53 so that Par - 4 enters circulation, thereby potentially targeting
tumor cells
at distant sites.
We describe an experimental model system that definitively links surgery and the subsequent wound - healing response to the outgrowth of
tumor cells
at distant anatomical
sites.
The therapy not only killed cells
at the primary
tumor site, but also in
distant metastases by «bystander» antitumor activity driven by the secreted MDA - 7 / IL - 24 protein.
The Ludwig Center
at the University of Chicago --- under the direction of Ralph Weichselbaum, MD, the Daniel K. Ludwig Professor and Chair of the Department of Radiation and Cellular Oncology, and Geoffrey Greene, PhD, the Daniel K. Ludwig Professor in the Ben May Cancer Research Institute
at the University of Chicago — will focus on metastasis, the process by which cancer cells migrate from a primary
tumor to multiple
distant sites.
When
tumors are too large for treatment or they have spread to
distant sites, therapy is aimed
at improving the quality of life of affected pets as much as possible.