Sentences with phrase «tumors by damaging»

Not exact matches

Researchers at the University of Cincinnati (UC) College of Medicine have shown that a new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart from damage — a direct result of the tumor.

This stress, which is notably induced in pre-cancerous lesions, is characterised by an increased DNA replication rate, which provokes DNA damage and genome instability, major drivers of tumor formation.

17 Epilepsy can be hereditary or caused by brain damage, infectious disease, or tumors.

High intensity, focused ultrasound can damage tissue by heating and cavitation, and has been used to ablate tumors and other lesions.

Tracheal damage can be caused by tumor, endotracheal intubation, blunt trauma, and other injuries.

The key to this approach is minimizing healthy tissue damage while maximizing cancerous tumor destruction of the sort that improves recognition of the tumor by the immune system.

A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.

This group's achievement shows the possibility to clarify the mechanism of human tumor formation, especially the molecular mechanism responsible for in the initial stage of cell cancerization due to DNA damaged by radiation in the initial stage, by using the model of budding yeast, a primitive eukaryote.

Arising from the Schwann cells of the vestibular (balance) nerve, these tumors can grow to the point of damaging nearby structures — and can lead to death by compressing the brainstem.

Only upon application is it «switched on» in the tumor tissue by visible light and damages the tumor tissue there.

The first long - term study of a pioneering endoscopic laser treatment for early vocal - cord cancer, developed at Massachusetts General Hospital (MGH) and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in curing patients» tumors while avoiding the damage to vocal quality caused by radiotherapy or by conventional laser or cold - instrument surgery.

Chemotherapies are potent toxins delivered into the bloodstream to kill tumor cells throughout the body by damaging DNA in rapidly dividing cells.

In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.

Moreover, in some cases, pancreatic cancer cells can even repair damage to their DNA caused by the chemotherapy drugs that do get into the tumor, further protecting themselves.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

Drugs like fluorouracil, oxaliplatin and irinotecan work by mimicking and damaging DNA molecules, or inhibiting enzymes involved in cell and DNA replication, slowing the uncontrolled growth of tumor cells.

In addition, they found that epithelial - derived MMP9 suppresses tumors in CAC by activating the MMP9 - Notch1 - ARF - p53 axis pathway, which increases apoptosis, initiates cell cycle arrest and keeps a check on DNA damage.

The cancer gene BRCA1, which keeps tumors in the breast and ovaries at bay by producing proteins that repair damaged DNA, may also regulate brain size.

The UV - B part of the spectrum suppresses the immune system and damages skin cells by mutating their DNA and, eventually, unleashing tumors.

Inhibition of ROS induced by reflux may be a useful strategy for preventing DNA damage and decreasing the risk for tumor formation caused by GERD, they concluded.

In different contexts, viruses appear capable of attacking tumors in a number of different ways — by directly infecting them, by releasing tumor proteins that trigger a broad immune response against the cancer, and by damaging the blood supply tumors need to survive.

Early observations suggesting that the virus might attack cancer in part by damaging blood vessels that feed tumor growth led the SillaJen team to strike up a collaboration with McDonald, an expert in tumor vasculature, to investigate the virus's mechanism of action in animal models.

If a bone has been damaged by the tumor or by removing the tumor, the orthopedic surgeon can usually reconstruct the bone to preserve function.

Topotecan works by trapping Top1ccs in tumor cells, resulting in the DNA damage that triggers apoptosis.

The accuracy of next - generation sequencing (NGS) for detecting tumor - specific mutations in plasma DNA is hindered by errors introduced during PCR / sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency.

On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins.

Still, by the 1990s DuPont knew that the chemical caused cancerous tumors in the testes, pancreases, and livers of lab animals, and there was even evidence of human DNA damage and links to prostate cancer in workers exposed to PFOA.

Chronic high salt intake can damage the lining of your stomach, making it more susceptible to infection by Helicobacter pylori, a bacterium that can cause inflammation and lead to tumor growth.

Notably, it contributes to tumor initiation by inducing oxidative stress, DNA damage, and chromosomal instability.

Prechemotherapy short - term fasting has been shown to help reduce tumor growth by supporting chemotherapies» efficacy; evidence also suggests it can lessen chemotherapies» damaging side effects.

Generally speaking, there are a small number of life - threatening tumors that can spread in the body, a large number of masses that cause damage inside the mouth, and a lot of swellings that are caused by inflammation and can look like other masses.

For example, oral x-rays allow a pet dentist to see decayed areas between teeth, jawbone damage caused by infections or cysts and tumors developing within the gums.

Cerebellar ataxia occurs when the cerebellum of the brain becomes damaged, often by a brain tumor or some kind of infection.

Mass lesions within the liver are often identified on ultrasound examination and can represent an area of liver healing (or regenerative nodule in a damaged region), a change in tissue content caused by storage of glycogen (starch, common in dogs with Cushing's Disease described below), infections (abscesses), biliary cysts, chronic fibrous tissue secondary to chronic hepatitis, or benign or malignant tumors.

Many cases of spinal and related nerve damage are due to sudden trauma, but some can result from encroachment of bone or tumors into the space occupied by the cord.

The mice with such damage subsequently suffered more and larger liver tumors induced by other chemical exposures.