Sentences with phrase «tumors formed by»

And we confirmed that the growth of the tumors formed by the human BCSCs transfected with the anti-miR-142-expressing lentivirus was significantly slower than those of the control tumors formed by the control lentivirus transfected BCSCs (Major points raised by the editors and the reviewers # 3) These data suggest that the regulation of APC and the Wnt signaling is at least one of the important pathways targeted by miR - 142 in human breast cancer cells and BCSCs.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

In tumors formed by human breast cancer cells, DNA damage (brown staining) is increased by simultaneous Olaparib treatment and PGAM1 suppression (right) when compared to either Olaparib treatment (left) or PGAM1 suppression (center) alone.

Olaparib had no effect on tumors formed by breast cancer cells containing functional BRCA1 and BRCA2 genes.

Not exact matches

Renal cell carcinoma, also known by the eponym Grawitz tumor, is the most common form of kidney cancer arising from the renal tubule.

Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often associated with a gloomy prognosis.

One form of pancreatic cancer has a new enemy: a two - drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.

When examined under a microscope, the tumors resemble immature embryonic kidneys, leading doctors to conclude that Wilms tumors form when kidney development, normally complete by birth, persists into childhood.

Pathologists classify tumors by how far their cells deviate from their normal forms, while hematologists identify and count different leukocytes by sight.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Aware that cancers rewire their metabolism in ways that could change the epigenome and that distant metastases in pancreatic cancer naturally spread to organs fed by a sugar - rich blood supply, the researchers wondered if the tumor cells had altered the way they use the basic form of sugar, glucose.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

In tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a week.

Studies have shown that stress might promote cancer indirectly by weakening the immune system's anti-tumor defense or by encouraging new tumor - feeding blood vessels to form.

«Another model is punctuated evolution in which CNAs are acquired in short bursts of crisis, followed by stable clonal expansion that form the tumor mass.

The memory and thinking problems experienced by cancer survivors, known as «chemo brain» or «chemo fog,» are not just the result of chemotherapy treatment, they may start as tumors form and develop, suggests a Baycrest - led study.

That light is absorbed by the chlorine - based molecules, which then excite nearby oxygen molecules, creating a highly reactive form of oxygen, known as singlet oxygen, that rips apart nearby biomolecules and kills the tumor cell.

Tracking sequence changes over time could also provide a kind of early warning system to identify the emergence of an aggressive form of the cancer by providing a real - time window into tumor evolution.

Recently, researchers led by Pier Paolo Pandolfi at Harvard Medical School found that PTEN's tumor suppressing activity becomes elevated when two copies of the protein bind together, forming a dimeric protein.

A study led by scientists from Harvard Medical School reveals «hidden» variability in how tumor cells are affected by anticancer drugs, offering new insights on why patients with the same form of cancer can have different responses to a drug.

An extension of this model, however, proposes that EMT forms a key mechanistic basis for the progression of malignant tumors (reviewed by Nieto MA [1]-RRB-.

In a study by Prasad and Dr. Nathan Gay, also of Oregon Health and Science University, nearly 70 percent of Americans die from forms of cancer for which there is no immunotherapy option, and for the rest who do qualify for immunotherapy, only 26 percent actually see their tumors shrink.

More important, by introducing miR - 200, they managed to activate production of E-cadherin protein and reverse tumors from a more - invasive mesenchymal into a less - invasive epithelial form.

«Circulating tumor cells (CTCs) have been shed by the original tumor and entered the bloodstream — they can then form into new tumors if they lodge in distant tissue,» Wang says.

These malignant tumors were formed by poorly delineated vascular channels lined by pleomorphic endothelial cells forming solid areas and with frequent mitotic figures.

CFE was calculated by dividing the number of tumor spheres formed by the original number of single cells seeded and is expressed as a percentage.

The knowledge about how this cancer form arises and develops is still limited but new results from a research team led by Lene Uhrbom, Uppsala University / SciLifeLab, shows that disease progress and the malignancy are affected by the cell type from which the tumor originates as well as the age of the patient.

Tumors» mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

The tumors formed in mice co-treated with chidamide and decitabine were significantly smaller than those that formed in untreated animals or those treated with the single agents, starting from 15 days of treatment (Figure 4C, left panel), as visualized by 18F - fluorodeoxyglucose small - animal positron emission tomography — computed tomography at 21 days of treatment (Figure 4C, right panel).

Germ cell tumors are masses of tissue formed by immature cells that normally would have developed into mature eggs (in a female) or sperm (in a male).

By comparison, canine transmissible venereal tumor, a sexually transmitted form of cancer that only affects dogs, has been around for at least 11,000 years and is generally not fatal to domesticated animals.

Adoptive Cell Transfer (ACT) is a form of immunotherapy that targets tumors specifically and potently by utilizing large numbers of a patient's own immune cells to target and destroy cancer cells.

Its structured data repository will integrate multiple characterizations of the immune response in tumors made by a working group formed by The Cancer Genome Atlas, led by the U.S. National Institutes of Health.

«By studying interactions between tumors and the bacteria in their microbiomes, we would better understand the bacteria's role in causing tumors to form and grow — if they even have such a role — and eventually, we may be able to treat cancer by changing aspects of its microbiome,» Dr. Blekhman saiBy studying interactions between tumors and the bacteria in their microbiomes, we would better understand the bacteria's role in causing tumors to form and grow — if they even have such a role — and eventually, we may be able to treat cancer by changing aspects of its microbiome,» Dr. Blekhman saiby changing aspects of its microbiome,» Dr. Blekhman said.

Although some tumors may be formed by initiating cells that do not resemble stem cells, it is likely that stem cell — like tumor cells are more aggressive at forming tumors, with a higher likelihood of relapse and metastasis.

Researchers led by St. Jude Children's Research Hospital scientists have worked out how a crucial cancer - related protein, a «histone writer» called Ezh2, plays a role in suppressing as well as driving the most aggressive form of the brain tumor medulloblastoma.

Wight's phenomenal size is caused by a tumor formed on his pituitary gland that caused growth spurts from the age of nine on.

Different types of tumors are formed by specific kinds of microbes.

A $ 2 million, seven - year clinical study funded by the National Institutes of Health and jointly conducted by the University of Minnesota and Bastyr University showed that Trametes versicolor, or turkey tail mushroom, in freeze - dried form, dramatically boosts immune function for women with Stage I - III breast cancer ─ possibly shrinking tumors.

And, although this effect may help to prevent heart attacks and other forms of heart disease, it may have the potential to promote cancer as well by increasing the growth of blood vessels in cancerous tumors.

While there are several different forms of cancer, they are all characterized by uncontrolled cell growth that typically forms a lump or tumor.

«Besides affecting tumor cells» directly, phytates «can act on [our] immune functions» by augmenting natural killer cell activity, the cells in our body that hunt down and dispose of cancer cells, as well as neutrophils, which help form our «first line of defense.»

Chappaqua, NY About Blog A Kids» Brain Tumor Cure Foundation (PLGA) helps to battle the most common forms of brain tumors in children by raising funds for medical research.

(Director: Jim Kohlberg; Screenwriters: Gwyn Lurie and Gary Marks, based on the story «The Last Hippie» by Oliver Sacks)-- A father struggles to bond with his estranged son who suffers a brain tumor that prevents him from forming new memories.

Lives adjusted to these breaks in rhythm the way a tree adjusts to a metal fence that stands in its path of growth — by growing around it, absorbing it, forming a tumor - like burl at the point of irritation.

«FLUTD may be caused by diseases of the bladder including, FIC, bacterial bladder infection, bladder stones, mucous plugs that form in the bladder and pass into the urethra, or bladder tumors — although these are uncommon in cats,» she said.

A further occurrence observed by some Veterinarians is that of a tumor or growth appearing directly on or around the sight of the annual injection, this is particularly noticeable in the feline world, and can take the form of fibrosarcoma.

Chappaqua, NY About Blog A Kids» Brain Tumor Cure Foundation (PLGA) helps to battle the most common forms of brain tumors in children by raising funds for medical research.

Chappaqua, NY About Blog A Kids» Brain Tumor Cure Foundation (PLGA) helps to battle the most common forms of brain tumors in children by raising funds for medical research.