Sentences with phrase «tumors in»

St. Jude scientists discover genes suspected to cause brain tumors in children.

The authors next took 997 tumors in the discovery set, integrated copy number and gene expression data, and performed clustering analyses to identify subgroups of tumors with distinct features and clinical outcomes.

However, their initial finding demonstrated that progenitor derived from iPSCs generated using lentiviral gene transduction led to the high incidence of highly aggressive tumors in immunodeficient mice after transplantation under the kidney capsule.

The same approach may also prove helpful in combating solid tumors in different organs, Tanyi said.

The American Lung Association estimates that over 150,000 Americans will die of primary lung tumors in 2015, making it the number one cancer killer of men and women in this country.

It can also do this by dividing and making more T cells so that these engineered T cells are capable of eradicating literally pounds of tumors in patients.

Another replication attempt supported a 2011 Science Translational Medicine report from Stanford computational biologist Atul Butte's lab that the ulcer drug Tagamet slows the growth of lung tumors in mice.

Bradner and Mitsiades had reported in Cell in 2011 that the inhibitor blocks the Myc cancer gene and thereby slows the growth of multiple myeloma tumors in mice.

Tumors in low - oxygen environments tend to be more resistant to therapy and spread more aggressively to other parts of the body.

«Agents that block the proteins — CDK4 / 6 inhibitors — have received Food and Drug administration approval for some patients with metastatic breast cancer, but they've also shown promise against others types of tumors in clinical trials.

The chronic exposure of a population to these toxic elements, which enter the body through the food chain and food, could increase the frequency of certain tumors in some territories.

In a meeting sponsored by the National Cancer Policy Forum of the National Academies» Institute of Medicine in Washington, D.C., Fan and 15 other experts in the field described the benefits of using pet dogs with naturally occurring (rather than laboratory - induced) tumors in early cancer drug trials.

To be able to treat cancer of the central nervous system (CNS) successfully, it is important to have very precise knowledge about the molecular characteristics of the tumors in order to «give them the right name.»

Mechanistically, CD8 + T cell depletion, IFN - γ neutralization, or implantation of tumors in IFN - γ receptor knockout mice abrogated the vessel perfusion enhancement and antitumor effects of ICB.

Tumors in this subtype «are associated with relatively indolent disease, are cured by surgery, and almost never recur,» Swanton says.

URBANA, Ill. — Years of research in University of Illinois scientist John Erdman's laboratory have demonstrated that lycopene, the bioactive red pigment found in tomatoes, reduces growth of prostate tumors in a variety of animal models.

The MIT team is now testing this approach to treat tumors in mice and is also working on ways to deliver the antibodies to specific types of cells.

Previous studies show that antibody treatments that inhibit the protein, called programmed cell death 1 (PD - 1), can shrink tumors in humans.

Family history of breast cancer continues to significantly increase chances of developing invasive breast tumors in women ages 65 and older, according to research published by a team led by Dejana Braithwaite, PhD, associate professor of oncology at Georgetown University School of Medicine and a member of Georgetown Lombardi Comprehensive Cancer Center.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

«Inhibition of the EZH2 pathway slows growth of tumors in mouse brain derived from glioma stem cells from the enhancing margin of human tumors.

Malignant tumors in transplant patients are usually blamed on an immune system weakened by drugs.

One idea the team is mulling is to implant in patients a bag of iPS - derived liver cells that are self - contained, so they can't seed tumors in a patient's tissues but can still produce A1ATD.

The absence of tumors in virgin Nrk mutant mice strongly suggests that the tumorigenesis is closely related to the proliferation of mammary epithelial cells during pregnancy.

The study builds on recent work by Tyler Jacks, the director of the Koch Institute, who has also used CRISPR to generate lung and liver tumors in mice.

Dr. Yang's team has developed the new class of protein - based contrast agents and tested one called ProCA32 that enabled a much earlier detection of liver cancer tumors in mice.

They've used a gun powered by pressurized helium to fire microscopic gold bullets, coated with genes, into skin cells surrounding tumors in mice.

«New MRI approach detects early liver tumors in mouse model of human disease.»

The study strongly suggests that copper is an essential factor for the growth of tumors in humans as well.

Almost 30 years ago, scientists discovered that colon tumors in humans usually acquire cancerous mutations in a particular order, but they haven't been able to accurately model this in mice until now.

Forty days later, the tumors in the immunized mice were one - tenth the size of those in the animals that did not get the vaccine.

«If the sex hormones were causing this effect, we'd see major changes in the relative rates of brain tumors in males and females at puberty.

Current methods of oxygenating tumors in patients includes breathing pure oxygen, putting patients in oxygen chambers or injecting liquids full of oxygen directly to the tumor site.

Yilmaz, who studies colon cancer and how it is influenced by genes, diet, and aging, decided to adapt this approach to generate colon tumors in mice.

PFOA exposure increases the risk of certain tumors in rodents, though it's unclear whether it raises the risk of cancer in humans.

«Radiation a risk factor for brain tumors in young people, study finds.»

Researchers in the Cedars - Sinai Samuel Oschin Comprehensive Cancer Institute eradicated solid tumors in laboratory mice using a novel combination of two targeted agents.

In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.

Last year, Wittrup showed that delivering antibodies and IL - 2, a signaling molecule that helps to boost immune responses, could halt the growth of aggressive melanoma tumors in mice for as long as the treatment was given.

The cancer gene BRCA1, which keeps tumors in the breast and ovaries at bay by producing proteins that repair damaged DNA, may also regulate brain size.

The researchers grafted breast or lung tumors in mice, allowed the tumors to grow to small size and removed these tumors surgically — essentially mimicking the situation in a human tumor patient in which the tumor is surgically removed as soon as possible after diagnosis.

Interestingly, the team showed that combining anti-angiogenic and immune - stimulating therapies in the treatment of tumors in mouse models resulted in better therapeutic outcomes by providing white blood cell gates through which they can infiltrate cancers.

In the new study, the researchers used a combination of four different therapies to activate both of the immune system's two branches, producing a coordinated attack that led to the complete disappearance of large, aggressive tumors in mice.

A few years ago Peperstraete stumbled on an article in a science journal about medical researchers using crossed laser beams to image and heat tumors in a patient without disturbing any of the surrounding tissue.

Researchers also can't draw inferences from a single sample on the frequency of tumors in the Neandertal population, he says.

But recent work shows that while these cancers lack estrogen receptors, progesterone receptors, and aren't driven by the gene HER2, up to a third of these tumors express the androgen receptor — clinical trials are underway to inhibit the androgen receptor in these tumors in much the same way that the drug Tamoxifen inhibits estrogen receptor in estrogen - receptor - positive breast cancers.

Then, they confirmed the importance of ERBB4 via immunohistochemistry analysis of Lapatinib - resistant tumors in mice.

Malignant tumors pose a major threat to survival largely because they shed mobile cells that can form secondary tumors in other tissues.

Beyond identifying the Sestrin1 gene as frequently altered in FL patients, the scientists demonstrated that Sestrin1 is able to suppress tumors in vivo.

A newly devised tumor - specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery, reports Alexander L. Vahrmeijer MD, PhD, head of the Image - guided Surgery group in the Department of Surgery at Leiden University Medical Center in the Netherlands.