Sentences with phrase «tumors in mice by»

First, they induced lung tumors in the mice by giving the mice chemicals.

The conjugate, which they named «chemocoxib A,» reduced growth of COX - 2 positive tumors in mice by 50 percent, but didn't have any effect on tumors that didn't express the enzyme.

But a new study reports that these tiny flecks of carbon can shrink tumors in mice by delivering chemotherapy drugs to cancer cells.

A study done at the Georgia State University has found that ginger extract can reduce a prostate tumor in mice by 56 %.

Not exact matches

TPA is a toxic chemical described as «a potent tumor promoter in mouse skin» by the Boston - based firm Cell Signaling Technology.

TPA is used by scientists to produce skin tumors in mice for research.

Capsaicin additionally produced a significant deceleration of the development of prostate tumors created simply by those human cell lines grown in mouse models.

Cyclooxygenase - 2 (COX - 2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1 / KO mice.

A combination of fostamatinib and paclitaxel reduced tumor size in six mice by up to 87 percent, compared with no shrinkage in six untreated animals after three weeks.

After five weeks, the combination treatment in the six mice decreased tumor size by up to 66 percent, compared with six mice treated with only paclitaxel.

In the study, published online today by Science Translational Medicine, researchers removed breast tumors from mice and placed biodegradable gels containing an immune - stimulating drug in the resulting empty spacIn the study, published online today by Science Translational Medicine, researchers removed breast tumors from mice and placed biodegradable gels containing an immune - stimulating drug in the resulting empty spacin the resulting empty space.

When researchers injected fresh breast cancer cells in the side opposite the original tumor site, the disease didn't recur in any of the mice, as the cancer was rejected by the immune system's memory.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocyteIn the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytein mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

One form of pancreatic cancer has a new enemy: a two - drug combination discovered by UF Health researchers that inhibits tumors and kills cancer cells in mouse models.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Researchers found that genetically disrupting this pathway, or using the FDA - approved Src kinase inhibitor dasatinib, increases PUMA levels and decreases tumor progression and metastasis in mice by up to fivefold.

The tumors in Sand's lab might be explained by the high dose, the fact that the mice were newborns, and the type of mouse, suggests Kay, who was involved with a past clinical trial administering AAV to the liver to treat hemophilia.

The researchers showed in mouse models that chronic skin inflammation caused by continuous skin contact with allergens contributes to tumor development.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

The tumors in the group given the larger dose decreased by an average of 80 percent during the treatment period, and after 30 days, tumor regrowth stopped in all the mice.

Scientists identified the specific proteins secreted by the parasite Toxoplasma gondii that cause the immune system in mice to attack established ovarian tumors.

By blocking these in lung endothelial cells, the researchers were able to slow lung tumor growth in mice and also reduce the spread of metastatic tumors.

BCL - 2 is present in high amounts in many tumors and helps cancer cells to survive, but when the BCL - 2 gene is blocked by MM41 in mice, the cancer cells succumb to apoptosis and die.»

The good bacteria seem to help the drugs by priming T cells, which Wargo's group reported were more abundant in the gut and tumors of the mice who got fecal transplants from responder patients.

In this study, the researchers tested the effects of Olaparib on the tumors formed by human breast cancer cells injected into mice.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

By deleting the gene that expresses p300, the researchers safely reduced Treg function and limited tumor growth in mice.

A combination of iron - oxide nanoparticles and an alternating magnetic field, which together generate heat, have activated an immune system response to tumors in mice according to an accepted manuscript by Dartmouth - Hitchcock Norris Cotton Center researchers in the journal Nanomedicine: Nanotechnology, Biology and Medicine released online on February 24, 2014.

By contrast, 16 out of 17 mice that produced annexin A2 in their cells developed metastatic tumors in the liver, lungs or abdominal cavity.

In two mouse models of pancreatic cancer, a single treatment consisting of intravenous delivery of the PMILs followed by localized delivery of near - infrared light to the tumor site via optical fibers resulted in significantly greater reduction in tumor size than did either treatment with XL184 or PDT with BPD alonIn two mouse models of pancreatic cancer, a single treatment consisting of intravenous delivery of the PMILs followed by localized delivery of near - infrared light to the tumor site via optical fibers resulted in significantly greater reduction in tumor size than did either treatment with XL184 or PDT with BPD alonin significantly greater reduction in tumor size than did either treatment with XL184 or PDT with BPD alonin tumor size than did either treatment with XL184 or PDT with BPD alone.

A new optogenetic technology developed by scientists at the University of Massachusetts Medical School and Texas A&M Health Science Center Institute of Biosciences & Technology, called optogenetic immunomodulation, is capable of turning on immune cells to attack melanoma tumors in mice.

By contrast, a signal of tumor activity increased sixty-fold in mice treated with the widely used chemotherapy drug gemcitabine.

In tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a weeIn tests in mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a weein mice with a very aggressive form of melanoma, the researchers found they could stop tumor growth by delivering this engineered form of IL - 2, along with antibody drugs, once a week.

They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.

The treatment resulted in a reduced tumor burden and extended the lifespans of the mice by more than 30 percent.

The mesothelioma caused by long carbon nanotubes mice was in many ways similar to tumor samples from patients.

Antibodies only bind to target cells Peptide antibodies developed by Kwak and co-discoverer, Hong Qin, Ph.D., assistant professor of Lymphoma / Myeloma, wipe out MDSCs in the blood, spleen and tumor cells of mice without binding to other white blood cells or dendritic cells involved in immune response.

In their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micIn their research, scientists at Rutgers created animal models that closely resemble the cancerous tumors found in women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory micin women with ovarian cancer by injecting tumor tissues obtained from gynecological cancer patients treated at the Cancer Institute into laboratory mice.

In the group that received the highest dose of nanotubes followed by a 30 - second laser treatment, the tumors shrank and completely disappeared in 80 percent of the micIn the group that received the highest dose of nanotubes followed by a 30 - second laser treatment, the tumors shrank and completely disappeared in 80 percent of the micin 80 percent of the mice.

While transplantation of T cells alone had only little impact on tumor size in cancerous mice, the researchers achieved substantial regression of the cancer by transplanting both T cells and activated eosinophils.

However, if these mice developed tumors, these were pervaded by significantly more blood vessels and, in addition, grew faster than in fellow animals with functioning Tie2 receptor.

By combining these two refinements, the researchers were able to enhance the sensitivity of the sensor 15-fold, which they showed was enough to detect ovarian cancer composed of small tumors (2 millimeters in diameter) in mice.

In her latest findings, published in the journal Oncogene, Barbolina demonstrated in a mouse model that by lowering production of the fractalkine receptor, tumors did not metastasize to nearby sites of the peritoneal wall, bowel or liveIn her latest findings, published in the journal Oncogene, Barbolina demonstrated in a mouse model that by lowering production of the fractalkine receptor, tumors did not metastasize to nearby sites of the peritoneal wall, bowel or livein the journal Oncogene, Barbolina demonstrated in a mouse model that by lowering production of the fractalkine receptor, tumors did not metastasize to nearby sites of the peritoneal wall, bowel or livein a mouse model that by lowering production of the fractalkine receptor, tumors did not metastasize to nearby sites of the peritoneal wall, bowel or liver.

«Eliminating endothelial CD146 by conditional knockout in two different mouse models of colitis significantly reduced the severity of inflammation and decreased tumor incidence and tumor progression in a mouse model of CAC,» reports lead investigator Xiyun Yan, PhD, from the Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing.

Interestingly, the team showed that combining anti-angiogenic and immune - stimulating therapies in the treatment of tumors in mouse models resulted in better therapeutic outcomes by providing white blood cell gates through which they can infiltrate cancers.

While previous research had shown some effectiveness of this molecule in a mouse model of ovarian cancer, that benefit was limited by the immunosuppressive environment within tumors, particularly the presence of regulatory T cells (Tregs).