Not exact matches
Desgrosellier said the team will follow up with
mouse models containing
tumor fragments from patients to better reflect the diversity
of cell types present
in human
disease.
With the help
of various
mouse models for pancreatic cancer, they have succeeded
in elucidating the molecular pathways
of tumor development
in detail and have gained a better understanding
of how various characteristics
of the
disease arise.
«New MRI approach detects early liver
tumors in mouse model of human
disease.»
It should be noted, however, that while a study on senescent cell ablation
in genetically normal
mice would provide at least some evidence on the effect
of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated
in a large mammal
model, since even normally - aging
mice rarely suffer metastatic
disease to the extent
of aging humans, as sheer primary
tumor volume is generally sufficient to be fatal to
mice.
Transgenic
models session Chairs V.Korinek & Z. Kozmik 16.00 Bohumil Fafílek Cell tracking and manipulation
in genetically modified
mice 16.30 Michaela Krausová
Mouse transgenic
model to study
tumor progression and metastasis
in the gut 17.00 coffee break 17.20 Matej Durik Rodent transgenic
models of cardiovascular
diseases 17.50 Jan Masek The role
of Wnt / beta - catenin signaling
in neural crest development: an insight from transgenic and knockout
mice 19.00 dinner
These kind
of mice are an extraordinary resource for
modeling human
disease; for instance, research has found that
mice that are genetically mutated to carry the BRCA1 gene (a human breast cancer gene) behave more similarly to human cancer patients than those
mice who have had a
tumor physically transplanted
in.